Development of cyclic peptides that can be administered orally to inhibit disease targets

Development of cyclic peptides that can be administered orally to inhibit disease targets

Cyclic peptides can bind challenging disease targets, but their oral application is hindered by digestion and absorption issues. We developed a versatile method for the synthesis and functional screening of vast numbers of synthetic cyclic peptides and identified peptides with high inhibitory activi...

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Veröffentlicht in:Nature chemical biology 2024-05, Vol.20 (5), p.551-552
Format: Artikel
Sprache:eng
Schlagworte:
631/154/1435/2163
631/154/309/2132/605
631/92/2132/605
639/638/309/2132/605
Administration, Oral
Animals
Bioavailability
Biochemical Engineering
Biochemistry
Bioorganic Chemistry
Cell Biology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Drug Development - methods
Humans
Ligands
Methods
Oral administration
Peptides
Peptides, Cyclic - administration & dosage
Peptides, Cyclic - chemistry
Peptides, Cyclic - pharmacology
Proteins
Research Briefing
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Beschreibung
Zusammenfassung:Cyclic peptides can bind challenging disease targets, but their oral application is hindered by digestion and absorption issues. We developed a versatile method for the synthesis and functional screening of vast numbers of synthetic cyclic peptides and identified peptides with high inhibitory activity, stability and oral bioavailability in rats.
ISSN:1552-4450
1552-4469
DOI:10.1038/s41589-023-01505-0