Chronic rhinosinusitis and olfaction after highly effective modulator therapy: The role of individual sinus inflammation
Key Points Individual sinus opacification (ISO) is measurable via a convolutional neural network approach. ISO decreased through 2 years after highly effective modulator therapy was initiated. In adults with cystic fibrosis, ISO did not correlate with quality of life or olfaction.
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| Veröffentlicht in: | International forum of allergy & rhinology 2024-05, Vol.14 (5), p.986-989 |
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| container_end_page | 989 |
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| container_issue | 5 |
| container_start_page | 986 |
| container_title | International forum of allergy & rhinology |
| container_volume | 14 |
| creator | Miller, Jessa E. Taylor‐Cousar, Jennifer L. Humphries, Stephen M. Khatiwada, Aastha Chen, Haidee Wilson, Alexandra Vladar, Eszter K. Lynch, David A. Li, Douglas A. Beswick, Daniel M. |
| description | Key Points
Individual sinus opacification (ISO) is measurable via a convolutional neural network approach.
ISO decreased through 2 years after highly effective modulator therapy was initiated.
In adults with cystic fibrosis, ISO did not correlate with quality of life or olfaction. |
| doi_str_mv | 10.1002/alr.23299 |
| format | Article |
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Individual sinus opacification (ISO) is measurable via a convolutional neural network approach.
ISO decreased through 2 years after highly effective modulator therapy was initiated.
In adults with cystic fibrosis, ISO did not correlate with quality of life or olfaction.</description><identifier>ISSN: 2042-6976</identifier><identifier>EISSN: 2042-6984</identifier><identifier>DOI: 10.1002/alr.23299</identifier><identifier>PMID: 38146638</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Chronic Disease ; chronic rhinosinusitis ; Cystic fibrosis ; Cystic Fibrosis - drug therapy ; elexacaftor/tezacaftor/ivacaftor ; Female ; Humans ; Male ; Middle Aged ; Neural networks ; Olfaction ; Olfaction Disorders - etiology ; Paranasal Sinuses ; Quality of Life ; Rhinosinusitis ; sinus opacification ; Smell - physiology</subject><ispartof>International forum of allergy & rhinology, 2024-05, Vol.14 (5), p.986-989</ispartof><rights>2023 ARS‐AAOA, LLC.</rights><rights>2024 ARS‐AAOA, LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-487a3616e2fae7b87485eae54b270bccc3211d264b7edcb5b3332677d15e737d3</citedby><cites>FETCH-LOGICAL-c3539-487a3616e2fae7b87485eae54b270bccc3211d264b7edcb5b3332677d15e737d3</cites><orcidid>0000-0002-5113-4530 ; 0000-0001-9769-187X ; 0000-0001-8612-5442</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Falr.23299$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Falr.23299$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38146638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miller, Jessa E.</creatorcontrib><creatorcontrib>Taylor‐Cousar, Jennifer L.</creatorcontrib><creatorcontrib>Humphries, Stephen M.</creatorcontrib><creatorcontrib>Khatiwada, Aastha</creatorcontrib><creatorcontrib>Chen, Haidee</creatorcontrib><creatorcontrib>Wilson, Alexandra</creatorcontrib><creatorcontrib>Vladar, Eszter K.</creatorcontrib><creatorcontrib>Lynch, David A.</creatorcontrib><creatorcontrib>Li, Douglas A.</creatorcontrib><creatorcontrib>Beswick, Daniel M.</creatorcontrib><title>Chronic rhinosinusitis and olfaction after highly effective modulator therapy: The role of individual sinus inflammation</title><title>International forum of allergy & rhinology</title><addtitle>Int Forum Allergy Rhinol</addtitle><description>Key Points
Individual sinus opacification (ISO) is measurable via a convolutional neural network approach.
ISO decreased through 2 years after highly effective modulator therapy was initiated.
In adults with cystic fibrosis, ISO did not correlate with quality of life or olfaction.</description><subject>Adult</subject><subject>Chronic Disease</subject><subject>chronic rhinosinusitis</subject><subject>Cystic fibrosis</subject><subject>Cystic Fibrosis - drug therapy</subject><subject>elexacaftor/tezacaftor/ivacaftor</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neural networks</subject><subject>Olfaction</subject><subject>Olfaction Disorders - etiology</subject><subject>Paranasal Sinuses</subject><subject>Quality of Life</subject><subject>Rhinosinusitis</subject><subject>sinus opacification</subject><subject>Smell - physiology</subject><issn>2042-6976</issn><issn>2042-6984</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1LJDEQhsOyyyrqwT8gAS_rYTRfnXTvTYZVFwaERc8hnVTsSLozJt268-_tcdTDwtaliuLhoagXoWNKzikh7MLEfM44a5ovaJ8RwRayqcXXz1nJPXRUyiOZq6JVRdV3tMdrKqTk9T76u-xyGoLFuQtDKmGYShhDwWZwOEVv7BjSgI0fIeMuPHRxg8F7mNfPgPvkpmjGlPHYQTbrzU981wHOKQJOHofBhefgJhPxm3he-Gj63mydh-ibN7HA0Xs_QPdXv-6WN4vV7fXv5eVqYXnFm4WoleGSSmDegGprJeoKDFSiZYq01lrOKHVMilaBs23Vcs6ZVMrRChRXjh-gHzvvOqenCcqo-1AsxGgGSFPRrCGSqqamZEZP_0Ef05SH-TrNiRBNo4TYUmc7yuZUSgav1zn0Jm80JXqbiJ4T0W-JzOzJu3Fqe3Cf5Mf_Z-BiB7yECJv_m_Tl6s9O-Qp-dpZb</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Miller, Jessa E.</creator><creator>Taylor‐Cousar, Jennifer L.</creator><creator>Humphries, Stephen M.</creator><creator>Khatiwada, Aastha</creator><creator>Chen, Haidee</creator><creator>Wilson, Alexandra</creator><creator>Vladar, Eszter K.</creator><creator>Lynch, David A.</creator><creator>Li, Douglas A.</creator><creator>Beswick, Daniel M.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5113-4530</orcidid><orcidid>https://orcid.org/0000-0001-9769-187X</orcidid><orcidid>https://orcid.org/0000-0001-8612-5442</orcidid></search><sort><creationdate>202405</creationdate><title>Chronic rhinosinusitis and olfaction after highly effective modulator therapy: The role of individual sinus inflammation</title><author>Miller, Jessa E. ; Taylor‐Cousar, Jennifer L. ; Humphries, Stephen M. ; Khatiwada, Aastha ; Chen, Haidee ; Wilson, Alexandra ; Vladar, Eszter K. ; Lynch, David A. ; Li, Douglas A. ; Beswick, Daniel M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-487a3616e2fae7b87485eae54b270bccc3211d264b7edcb5b3332677d15e737d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Chronic Disease</topic><topic>chronic rhinosinusitis</topic><topic>Cystic fibrosis</topic><topic>Cystic Fibrosis - drug therapy</topic><topic>elexacaftor/tezacaftor/ivacaftor</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neural networks</topic><topic>Olfaction</topic><topic>Olfaction Disorders - etiology</topic><topic>Paranasal Sinuses</topic><topic>Quality of Life</topic><topic>Rhinosinusitis</topic><topic>sinus opacification</topic><topic>Smell - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miller, Jessa E.</creatorcontrib><creatorcontrib>Taylor‐Cousar, Jennifer L.</creatorcontrib><creatorcontrib>Humphries, Stephen M.</creatorcontrib><creatorcontrib>Khatiwada, Aastha</creatorcontrib><creatorcontrib>Chen, Haidee</creatorcontrib><creatorcontrib>Wilson, Alexandra</creatorcontrib><creatorcontrib>Vladar, Eszter K.</creatorcontrib><creatorcontrib>Lynch, David A.</creatorcontrib><creatorcontrib>Li, Douglas A.</creatorcontrib><creatorcontrib>Beswick, Daniel M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International forum of allergy & rhinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miller, Jessa E.</au><au>Taylor‐Cousar, Jennifer L.</au><au>Humphries, Stephen M.</au><au>Khatiwada, Aastha</au><au>Chen, Haidee</au><au>Wilson, Alexandra</au><au>Vladar, Eszter K.</au><au>Lynch, David A.</au><au>Li, Douglas A.</au><au>Beswick, Daniel M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic rhinosinusitis and olfaction after highly effective modulator therapy: The role of individual sinus inflammation</atitle><jtitle>International forum of allergy & rhinology</jtitle><addtitle>Int Forum Allergy Rhinol</addtitle><date>2024-05</date><risdate>2024</risdate><volume>14</volume><issue>5</issue><spage>986</spage><epage>989</epage><pages>986-989</pages><issn>2042-6976</issn><eissn>2042-6984</eissn><abstract>Key Points
Individual sinus opacification (ISO) is measurable via a convolutional neural network approach.
ISO decreased through 2 years after highly effective modulator therapy was initiated.
In adults with cystic fibrosis, ISO did not correlate with quality of life or olfaction.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38146638</pmid><doi>10.1002/alr.23299</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-5113-4530</orcidid><orcidid>https://orcid.org/0000-0001-9769-187X</orcidid><orcidid>https://orcid.org/0000-0001-8612-5442</orcidid></addata></record> |
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| ispartof | International forum of allergy & rhinology, 2024-05, Vol.14 (5), p.986-989 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Chronic Disease chronic rhinosinusitis Cystic fibrosis Cystic Fibrosis - drug therapy elexacaftor/tezacaftor/ivacaftor Female Humans Male Middle Aged Neural networks Olfaction Olfaction Disorders - etiology Paranasal Sinuses Quality of Life Rhinosinusitis sinus opacification Smell - physiology |
| title | Chronic rhinosinusitis and olfaction after highly effective modulator therapy: The role of individual sinus inflammation |
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