Synthesis of new versatile functionalized polyesters for biomedical applications
A new family of branched polymers was synthesized for different biomedical applications such as the preparation of targeted nanoparticulate drug carriers. They are new copolymers of hydroxy-acids and allyl glycidyl ether. The functional groups (allyl-, hydroxyl- and carboxyl-) to which various group...
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| Veröffentlicht in: | Polymer (Guilford) 2005-11, Vol.46 (25), p.11263-11272 |
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| container_title | Polymer (Guilford) |
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| creator | Nadeau, Véronique Leclair, Grégoire Sant, Shilpa Rabanel, Jean-Michel Quesnel, Richard Hildgen, Patrice |
| description | A new family of branched polymers was synthesized for different biomedical applications such as the preparation of targeted nanoparticulate drug carriers. They are new copolymers of hydroxy-acids and allyl glycidyl ether. The functional groups (allyl-, hydroxyl- and carboxyl-) to which various groups will be grafted are linked to the polymer backbone. The resulting polymers were characterized by
1H NMR,
13C NMR, size exclusion chromatography (SEC), elemental analysis and differential scanning calorimetry (DSC). In vitro cytotoxicity assays were also conducted to ensure biocompatibility of the polymers. In order to obtain some structural evidences, different molecules have been grafted on the pendant groups. The method allows a rapid and easy synthesis of allyl-, hydroxyl- and carboxyl-branched degradable polymers for grafting various bioactive molecules. |
| doi_str_mv | 10.1016/j.polymer.2005.09.079 |
| format | Article |
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1H NMR,
13C NMR, size exclusion chromatography (SEC), elemental analysis and differential scanning calorimetry (DSC). In vitro cytotoxicity assays were also conducted to ensure biocompatibility of the polymers. In order to obtain some structural evidences, different molecules have been grafted on the pendant groups. The method allows a rapid and easy synthesis of allyl-, hydroxyl- and carboxyl-branched degradable polymers for grafting various bioactive molecules.</description><identifier>ISSN: 0032-3861</identifier><identifier>EISSN: 1873-2291</identifier><identifier>DOI: 10.1016/j.polymer.2005.09.079</identifier><identifier>CODEN: POLMAG</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Applied sciences ; Bioadhesive ; Biocompatible ; Branched polymer ; Copolymerization ; Exact sciences and technology ; Organic polymers ; Physicochemistry of polymers ; Preparation, kinetics, thermodynamics, mechanism and catalysts</subject><ispartof>Polymer (Guilford), 2005-11, Vol.46 (25), p.11263-11272</ispartof><rights>2005 Elsevier Ltd</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-5361a568018de1fb475267c7fa1d3d0a9ae644bb5ff8a9e6b46492b97bebebf33</citedby><cites>FETCH-LOGICAL-c442t-5361a568018de1fb475267c7fa1d3d0a9ae644bb5ff8a9e6b46492b97bebebf33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0032386105014291$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17277094$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Nadeau, Véronique</creatorcontrib><creatorcontrib>Leclair, Grégoire</creatorcontrib><creatorcontrib>Sant, Shilpa</creatorcontrib><creatorcontrib>Rabanel, Jean-Michel</creatorcontrib><creatorcontrib>Quesnel, Richard</creatorcontrib><creatorcontrib>Hildgen, Patrice</creatorcontrib><title>Synthesis of new versatile functionalized polyesters for biomedical applications</title><title>Polymer (Guilford)</title><description>A new family of branched polymers was synthesized for different biomedical applications such as the preparation of targeted nanoparticulate drug carriers. They are new copolymers of hydroxy-acids and allyl glycidyl ether. The functional groups (allyl-, hydroxyl- and carboxyl-) to which various groups will be grafted are linked to the polymer backbone. The resulting polymers were characterized by
1H NMR,
13C NMR, size exclusion chromatography (SEC), elemental analysis and differential scanning calorimetry (DSC). In vitro cytotoxicity assays were also conducted to ensure biocompatibility of the polymers. In order to obtain some structural evidences, different molecules have been grafted on the pendant groups. The method allows a rapid and easy synthesis of allyl-, hydroxyl- and carboxyl-branched degradable polymers for grafting various bioactive molecules.</description><subject>Applied sciences</subject><subject>Bioadhesive</subject><subject>Biocompatible</subject><subject>Branched polymer</subject><subject>Copolymerization</subject><subject>Exact sciences and technology</subject><subject>Organic polymers</subject><subject>Physicochemistry of polymers</subject><subject>Preparation, kinetics, thermodynamics, mechanism and catalysts</subject><issn>0032-3861</issn><issn>1873-2291</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqFkF1L7DAQhoMouHr8CUJv9K49kzRpmisR8eOAoHD0OqTpBLN0m5p0lfXXm2UXvJS5yECemXd4CDmnUFGgzd9lNYVhs8JYMQBRgapAqgOyoK2sS8YUPSQLgJqVddvQY3KS0hIAmGB8QZ7_b8b5DZNPRXDFiJ_FB8ZkZj9g4dajnX0YzeC_sC-2IZjm_F24EIvOhxX23pqhMNM05GbLpj_kyJkh4dn-PSWvd7cvNw_l49P9v5vrx9JyzuZS1A01ommBtj1S13EpWCOtdIb2dQ9GGWw47zrhXGsUNh1vuGKdkh3mcnV9Si53e6cY3tf5Lr3yyeIwmBHDOmmmQEipxO9gKymrqcqg2IE2hpQiOj1FvzJxoynorWi91HvReitag9JZdJ672AeYlG24aEbr08-wZFKC4pm72nGYtXz4vCVZj6PNEiPaWffB_5L0DfLLmPc</recordid><startdate>20051128</startdate><enddate>20051128</enddate><creator>Nadeau, Véronique</creator><creator>Leclair, Grégoire</creator><creator>Sant, Shilpa</creator><creator>Rabanel, Jean-Michel</creator><creator>Quesnel, Richard</creator><creator>Hildgen, Patrice</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope></search><sort><creationdate>20051128</creationdate><title>Synthesis of new versatile functionalized polyesters for biomedical applications</title><author>Nadeau, Véronique ; Leclair, Grégoire ; Sant, Shilpa ; Rabanel, Jean-Michel ; Quesnel, Richard ; Hildgen, Patrice</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-5361a568018de1fb475267c7fa1d3d0a9ae644bb5ff8a9e6b46492b97bebebf33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Applied sciences</topic><topic>Bioadhesive</topic><topic>Biocompatible</topic><topic>Branched polymer</topic><topic>Copolymerization</topic><topic>Exact sciences and technology</topic><topic>Organic polymers</topic><topic>Physicochemistry of polymers</topic><topic>Preparation, kinetics, thermodynamics, mechanism and catalysts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nadeau, Véronique</creatorcontrib><creatorcontrib>Leclair, Grégoire</creatorcontrib><creatorcontrib>Sant, Shilpa</creatorcontrib><creatorcontrib>Rabanel, Jean-Michel</creatorcontrib><creatorcontrib>Quesnel, Richard</creatorcontrib><creatorcontrib>Hildgen, Patrice</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><jtitle>Polymer (Guilford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nadeau, Véronique</au><au>Leclair, Grégoire</au><au>Sant, Shilpa</au><au>Rabanel, Jean-Michel</au><au>Quesnel, Richard</au><au>Hildgen, Patrice</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of new versatile functionalized polyesters for biomedical applications</atitle><jtitle>Polymer (Guilford)</jtitle><date>2005-11-28</date><risdate>2005</risdate><volume>46</volume><issue>25</issue><spage>11263</spage><epage>11272</epage><pages>11263-11272</pages><issn>0032-3861</issn><eissn>1873-2291</eissn><coden>POLMAG</coden><abstract>A new family of branched polymers was synthesized for different biomedical applications such as the preparation of targeted nanoparticulate drug carriers. They are new copolymers of hydroxy-acids and allyl glycidyl ether. The functional groups (allyl-, hydroxyl- and carboxyl-) to which various groups will be grafted are linked to the polymer backbone. The resulting polymers were characterized by
1H NMR,
13C NMR, size exclusion chromatography (SEC), elemental analysis and differential scanning calorimetry (DSC). In vitro cytotoxicity assays were also conducted to ensure biocompatibility of the polymers. In order to obtain some structural evidences, different molecules have been grafted on the pendant groups. The method allows a rapid and easy synthesis of allyl-, hydroxyl- and carboxyl-branched degradable polymers for grafting various bioactive molecules.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.polymer.2005.09.079</doi><tpages>10</tpages></addata></record> |
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| ispartof | Polymer (Guilford), 2005-11, Vol.46 (25), p.11263-11272 |
| issn | 0032-3861 1873-2291 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Applied sciences Bioadhesive Biocompatible Branched polymer Copolymerization Exact sciences and technology Organic polymers Physicochemistry of polymers Preparation, kinetics, thermodynamics, mechanism and catalysts |
| title | Synthesis of new versatile functionalized polyesters for biomedical applications |
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