Relevance of NAT2 genotype and clinical factors to risk for antituberculosis drug-induced liver injury

Relevance of NAT2 genotype and clinical factors to risk for antituberculosis drug-induced liver injury

The study analyzes the risk factors associated with antituberculosis drug-induced liver injury (ATB-DILI) and the relationship between ATB-DILI and gene polymorphisms. Out of the 324 included patients, 57 (17.59%) developed ATB-DILI. Age, history of liver disease, alcohol consumption and timing of a...

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Veröffentlicht in:Pharmacogenomics 2024-01, Vol.25 (1), p.21-28
Hauptverfasser: Cheng, Fang, Qiu, Chao-Chao, Jiang, Xian-Gao, Wu, Te, Zhang, Qiang, Chen, Xin, Zheng, Shi-Lin, Liu, Sai-Duo, Ye, Xin-Chun, Shi, Ji-Chan
Format: Artikel
Sprache:eng
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Zusammenfassung:The study analyzes the risk factors associated with antituberculosis drug-induced liver injury (ATB-DILI) and the relationship between ATB-DILI and gene polymorphisms. Out of the 324 included patients, 57 (17.59%) developed ATB-DILI. Age, history of liver disease, alcohol consumption and timing of antituberculosis (ATB) treatment were independent risk factors for ATB-DILI in the patients with tuberculosis (TB; p 
ISSN:1462-2416
1744-8042
DOI:10.2217/pgs-2023-0148