Crystal, Solution, and Computational Study of the Structure of Ortho‐Lithium N,N‐Diisopropyl‐P,P‐Diphenylphosphinothioic Amide

The first crystal structure of an ortho‐lithium phosphinothioic amide complexed with tetramethylethylenediamine 12 is reported. The complex consists of a spirane in which the spiro‐lithium is N,N‐ and C,S‐chelated by the diamine and organophosphorus ligands, respectively. The analogous ortho anion 14 obtained by Sn(IV)/Li transmetallation in THF has also been synthesized. Nuclear magnetic resonance study of both anions showed that they exist as monomers in solution and are involved in dynamic processes including the restricted rotation around the P−N bond. 14 is converted at room temperature by nucleophilic cyclization to the dearomatized anion 15, which evolves after a few hours to the benzophosphindole sulfide 16. Density functional theory calculations supported the aggregation state in solution and were used to explore the conformational space of anion 12, the mechanism of ortho‐lithiation directed by P(X)−N (X=O, S) groups, and the mechanism of formation of 15. Ortho‐lithiated phosphinothioic amides have been structurally characterized by X‐ray diffraction and NMR spectroscopy in solution for the first time. DFT studies supported the existence of monomeric lithiated compounds and provided insight into their conformational behavior and the DoLi mechanism. The ortho anion transformed into a benzo[b]phosphindole 5‐sulfide via a dearomatized species characterized by NMR spectroscopy.