Tailoring allocation policies and improving access to paediatric liver transplantation over a 16-year period

Tailoring allocation policies and improving access to paediatric liver transplantation over a 16-year period

Mortality on the paediatric liver transplantation (pLT) waiting list (WL) is still an issue. We analysed the Italian pLT WL to evaluate the intention-to-treat (ITT) success rate and to identify factors influencing success. All children (25 kg, blood group O or awaiting pLT combined with other organs...

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Veröffentlicht in:Journal of hepatology 2024-03, Vol.80 (3), p.505-514
Hauptverfasser: Spada, Marco, Angelico, Roberta, Trapani, Silvia, Masiero, Lucia, Puoti, Francesca, Colledan, Michele, Cintorino, Davide, Romagnoli, Renato, Cillo, Umberto, Cardillo, Massimo
Format: Artikel
Sprache:eng
Schlagworte:
organ allocation system
outcomes
pediatric liver transplantation
split liver transplantation
waiting list
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Zusammenfassung:Mortality on the paediatric liver transplantation (pLT) waiting list (WL) is still an issue. We analysed the Italian pLT WL to evaluate the intention-to-treat (ITT) success rate and to identify factors influencing success. All children (25 kg, blood group O or awaiting pLT combined with other organs had less chance of being transplanted. ITT patient survival rates were 90.5% at 1 year and 87.5% at 5 years, remaining stable across eras. Risk factors for ITT survival were re-transplantation (HR 5.83, p
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2023.11.031