Effects of L-Leucine Supplementation and Resistance Training on Adipokine Markers in Untrained Perimenopausal and Postmenopausal Women
Chapman-Lopez, TJ, Funderburk, LK, Heileson, JL, Wilburn, DT, Koutakis, P, Gallucci, AR, and Forsse, JS. Effects of L-leucine supplementation and resistance training on adipokine markers in untrained perimenopausal and postmenopausal women. J Strength Cond Res 38(3): 526-532, 2024-This study examine...
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description | Chapman-Lopez, TJ, Funderburk, LK, Heileson, JL, Wilburn, DT, Koutakis, P, Gallucci, AR, and Forsse, JS. Effects of L-leucine supplementation and resistance training on adipokine markers in untrained perimenopausal and postmenopausal women. J Strength Cond Res 38(3): 526-532, 2024-This study examined the effects of supplementing 5 g of leucine compared with a placebo during a 10-week resistance training program on body composition parameters and adipokine concentrations in untrained, perimenopausal and postmenopausal women. Thirty-five women were randomly assigned to 2 groups-leucine (LEU, n = 17) and placebo (PLC, n = 18)-in a double-blind, placebo-controlled trial. Each group consumed the supplement or placebo every day and completed a resistance training program for 10 weeks. Using 3-day food records, a diet was assessed before the intervention and after its cessation. Body composition was assessed preintervention and postintervention using dual-energy x-ray absorptiometry. Moreover, the concentrations of adipokines, such as adiponectin, visfatin, leptin, and monocyte chemoattractant protein-1 (MCP-1), were assessed preintervention and postintervention. Both groups showed an increase in visceral adipose tissue (VAT) area ( p = 0.030) and fat-free mass (FFM; p = 0.023). There were significant group differences in concentrations of visfatin ( p = 0.020) and leptin ( p = 0.038) between the PLC and LEU groups. Visfatin displayed higher concentrations in the PLC group and leptin displayed higher concentrations in the LEU group. In addition, there were significant decreases in adiponectin concentrations for both groups (LEU: 652 ± 513 to 292 ± 447 pg·ml -1 ; PLC: 584 ± 572 to 245 ± 356 pg·ml -1 , p = 0.002) and MCP-1 only decreased in the PLC group (253 ± 119 to 206 ± 106 pg·ml -1 , p = 0.004). There were significant decreases in adiponectin concentrations in both groups and a decrease in MCP-1 concentrations in the PLC group. These decreases may be due to both adipokines possible relationship with VAT area. However, it is not known whether leucine has underlying properties that hinder changes in MCP-1 concentrations. |
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Effects of L-leucine supplementation and resistance training on adipokine markers in untrained perimenopausal and postmenopausal women. J Strength Cond Res 38(3): 526-532, 2024-This study examined the effects of supplementing 5 g of leucine compared with a placebo during a 10-week resistance training program on body composition parameters and adipokine concentrations in untrained, perimenopausal and postmenopausal women. Thirty-five women were randomly assigned to 2 groups-leucine (LEU, n = 17) and placebo (PLC, n = 18)-in a double-blind, placebo-controlled trial. Each group consumed the supplement or placebo every day and completed a resistance training program for 10 weeks. Using 3-day food records, a diet was assessed before the intervention and after its cessation. Body composition was assessed preintervention and postintervention using dual-energy x-ray absorptiometry. Moreover, the concentrations of adipokines, such as adiponectin, visfatin, leptin, and monocyte chemoattractant protein-1 (MCP-1), were assessed preintervention and postintervention. Both groups showed an increase in visceral adipose tissue (VAT) area ( p = 0.030) and fat-free mass (FFM; p = 0.023). There were significant group differences in concentrations of visfatin ( p = 0.020) and leptin ( p = 0.038) between the PLC and LEU groups. Visfatin displayed higher concentrations in the PLC group and leptin displayed higher concentrations in the LEU group. In addition, there were significant decreases in adiponectin concentrations for both groups (LEU: 652 ± 513 to 292 ± 447 pg·ml -1 ; PLC: 584 ± 572 to 245 ± 356 pg·ml -1 , p = 0.002) and MCP-1 only decreased in the PLC group (253 ± 119 to 206 ± 106 pg·ml -1 , p = 0.004). There were significant decreases in adiponectin concentrations in both groups and a decrease in MCP-1 concentrations in the PLC group. These decreases may be due to both adipokines possible relationship with VAT area. However, it is not known whether leucine has underlying properties that hinder changes in MCP-1 concentrations.</description><identifier>ISSN: 1064-8011</identifier><identifier>EISSN: 1533-4287</identifier><identifier>DOI: 10.1519/JSC.0000000000004661</identifier><identifier>PMID: 38088883</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins Ovid Technologies</publisher><subject>Adipokines - pharmacology ; Adiponectin ; Adipose tissue ; Body Composition ; Dietary Supplements ; Dual energy X-ray absorptiometry ; Fat-free body mass ; Female ; Humans ; Leptin ; Leucine ; Leucine - pharmacology ; Monocyte chemoattractant protein ; Monocyte chemoattractant protein 1 ; Monocytes ; Nicotinamide Phosphoribosyltransferase - pharmacology ; Perimenopause ; Physical training ; Placebos ; Post-menopause ; Postmenopause ; Resistance Training ; Strength training</subject><ispartof>Journal of strength and conditioning research, 2024-03, Vol.38 (3), p.526-532</ispartof><rights>Copyright © 2023 National Strength and Conditioning Association.</rights><rights>2023 National Strength and Conditioning Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c284t-ec4911b444aac69ec585bd686c0c779a5f8198e25ecb5f409210f67987426b243</cites><orcidid>0000-0001-8326-5132</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38088883$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chapman-Lopez, Tomas J</creatorcontrib><creatorcontrib>Funderburk, LesLee K</creatorcontrib><creatorcontrib>Heileson, Jeffery L</creatorcontrib><creatorcontrib>Wilburn, Dylan T</creatorcontrib><creatorcontrib>Koutakis, Panagiotis</creatorcontrib><creatorcontrib>Gallucci, Andrew R</creatorcontrib><creatorcontrib>Forsse, Jeffrey S</creatorcontrib><title>Effects of L-Leucine Supplementation and Resistance Training on Adipokine Markers in Untrained Perimenopausal and Postmenopausal Women</title><title>Journal of strength and conditioning research</title><addtitle>J Strength Cond Res</addtitle><description>Chapman-Lopez, TJ, Funderburk, LK, Heileson, JL, Wilburn, DT, Koutakis, P, Gallucci, AR, and Forsse, JS. Effects of L-leucine supplementation and resistance training on adipokine markers in untrained perimenopausal and postmenopausal women. J Strength Cond Res 38(3): 526-532, 2024-This study examined the effects of supplementing 5 g of leucine compared with a placebo during a 10-week resistance training program on body composition parameters and adipokine concentrations in untrained, perimenopausal and postmenopausal women. Thirty-five women were randomly assigned to 2 groups-leucine (LEU, n = 17) and placebo (PLC, n = 18)-in a double-blind, placebo-controlled trial. Each group consumed the supplement or placebo every day and completed a resistance training program for 10 weeks. Using 3-day food records, a diet was assessed before the intervention and after its cessation. Body composition was assessed preintervention and postintervention using dual-energy x-ray absorptiometry. Moreover, the concentrations of adipokines, such as adiponectin, visfatin, leptin, and monocyte chemoattractant protein-1 (MCP-1), were assessed preintervention and postintervention. Both groups showed an increase in visceral adipose tissue (VAT) area ( p = 0.030) and fat-free mass (FFM; p = 0.023). There were significant group differences in concentrations of visfatin ( p = 0.020) and leptin ( p = 0.038) between the PLC and LEU groups. Visfatin displayed higher concentrations in the PLC group and leptin displayed higher concentrations in the LEU group. In addition, there were significant decreases in adiponectin concentrations for both groups (LEU: 652 ± 513 to 292 ± 447 pg·ml -1 ; PLC: 584 ± 572 to 245 ± 356 pg·ml -1 , p = 0.002) and MCP-1 only decreased in the PLC group (253 ± 119 to 206 ± 106 pg·ml -1 , p = 0.004). There were significant decreases in adiponectin concentrations in both groups and a decrease in MCP-1 concentrations in the PLC group. These decreases may be due to both adipokines possible relationship with VAT area. However, it is not known whether leucine has underlying properties that hinder changes in MCP-1 concentrations.</description><subject>Adipokines - pharmacology</subject><subject>Adiponectin</subject><subject>Adipose tissue</subject><subject>Body Composition</subject><subject>Dietary Supplements</subject><subject>Dual energy X-ray absorptiometry</subject><subject>Fat-free body mass</subject><subject>Female</subject><subject>Humans</subject><subject>Leptin</subject><subject>Leucine</subject><subject>Leucine - pharmacology</subject><subject>Monocyte chemoattractant protein</subject><subject>Monocyte chemoattractant protein 1</subject><subject>Monocytes</subject><subject>Nicotinamide Phosphoribosyltransferase - pharmacology</subject><subject>Perimenopause</subject><subject>Physical training</subject><subject>Placebos</subject><subject>Post-menopause</subject><subject>Postmenopause</subject><subject>Resistance Training</subject><subject>Strength training</subject><issn>1064-8011</issn><issn>1533-4287</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1OJCEUhYlx4v8bGEPixk05QAEFS9NpfyY9mc60xmWFom4ZtBpKqFr4Aj639KgT491wL_c7J5CD0DEl51RQ_fPXanZOvhSXkm6hPSrKsuBMVdu5J5IXilC6i_ZTeiSECSHKHbRbKqJylXvodd51YMeEQ4cXxQIm6zzg1TQMPazBj2Z0wWPjW_wXkkuj8RbwbTTOO_-A8-qidUN42oh-m_gEMWHn8Z0fNwi0eAnRZZ8wmCmZ_p_RMqTxy9V9yMMh-tGZPsHRx3mA7i7nt7PrYvHn6mZ2sSgsU3wswHJNacM5N8ZKDVYo0bRSSUtsVWkjOkW1AibANqLjRDNKOllpVXEmG8bLA3T27jvE8DxBGuu1Sxb63ngIU6qZJkxXXCqa0dNv6GOYos-vy1TJuJBMsEzxd8rGkFKErh7yh018qSmpNznVOaf6e05ZdvJhPjVraP-LPoMp3wDPuI6e</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Chapman-Lopez, Tomas J</creator><creator>Funderburk, LesLee K</creator><creator>Heileson, Jeffery L</creator><creator>Wilburn, Dylan T</creator><creator>Koutakis, Panagiotis</creator><creator>Gallucci, Andrew R</creator><creator>Forsse, Jeffrey S</creator><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8326-5132</orcidid></search><sort><creationdate>20240301</creationdate><title>Effects of L-Leucine Supplementation and Resistance Training on Adipokine Markers in Untrained Perimenopausal and Postmenopausal Women</title><author>Chapman-Lopez, Tomas J ; Funderburk, LesLee K ; Heileson, Jeffery L ; Wilburn, Dylan T ; Koutakis, Panagiotis ; Gallucci, Andrew R ; Forsse, Jeffrey S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-ec4911b444aac69ec585bd686c0c779a5f8198e25ecb5f409210f67987426b243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adipokines - pharmacology</topic><topic>Adiponectin</topic><topic>Adipose tissue</topic><topic>Body Composition</topic><topic>Dietary Supplements</topic><topic>Dual energy X-ray absorptiometry</topic><topic>Fat-free body mass</topic><topic>Female</topic><topic>Humans</topic><topic>Leptin</topic><topic>Leucine</topic><topic>Leucine - pharmacology</topic><topic>Monocyte chemoattractant protein</topic><topic>Monocyte chemoattractant protein 1</topic><topic>Monocytes</topic><topic>Nicotinamide Phosphoribosyltransferase - pharmacology</topic><topic>Perimenopause</topic><topic>Physical training</topic><topic>Placebos</topic><topic>Post-menopause</topic><topic>Postmenopause</topic><topic>Resistance Training</topic><topic>Strength training</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chapman-Lopez, Tomas J</creatorcontrib><creatorcontrib>Funderburk, LesLee K</creatorcontrib><creatorcontrib>Heileson, Jeffery L</creatorcontrib><creatorcontrib>Wilburn, Dylan T</creatorcontrib><creatorcontrib>Koutakis, Panagiotis</creatorcontrib><creatorcontrib>Gallucci, Andrew R</creatorcontrib><creatorcontrib>Forsse, Jeffrey S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of strength and conditioning research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chapman-Lopez, Tomas J</au><au>Funderburk, LesLee K</au><au>Heileson, Jeffery L</au><au>Wilburn, Dylan T</au><au>Koutakis, Panagiotis</au><au>Gallucci, Andrew R</au><au>Forsse, Jeffrey S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of L-Leucine Supplementation and Resistance Training on Adipokine Markers in Untrained Perimenopausal and Postmenopausal Women</atitle><jtitle>Journal of strength and conditioning research</jtitle><addtitle>J Strength Cond Res</addtitle><date>2024-03-01</date><risdate>2024</risdate><volume>38</volume><issue>3</issue><spage>526</spage><epage>532</epage><pages>526-532</pages><issn>1064-8011</issn><eissn>1533-4287</eissn><abstract>Chapman-Lopez, TJ, Funderburk, LK, Heileson, JL, Wilburn, DT, Koutakis, P, Gallucci, AR, and Forsse, JS. Effects of L-leucine supplementation and resistance training on adipokine markers in untrained perimenopausal and postmenopausal women. J Strength Cond Res 38(3): 526-532, 2024-This study examined the effects of supplementing 5 g of leucine compared with a placebo during a 10-week resistance training program on body composition parameters and adipokine concentrations in untrained, perimenopausal and postmenopausal women. Thirty-five women were randomly assigned to 2 groups-leucine (LEU, n = 17) and placebo (PLC, n = 18)-in a double-blind, placebo-controlled trial. Each group consumed the supplement or placebo every day and completed a resistance training program for 10 weeks. Using 3-day food records, a diet was assessed before the intervention and after its cessation. Body composition was assessed preintervention and postintervention using dual-energy x-ray absorptiometry. Moreover, the concentrations of adipokines, such as adiponectin, visfatin, leptin, and monocyte chemoattractant protein-1 (MCP-1), were assessed preintervention and postintervention. Both groups showed an increase in visceral adipose tissue (VAT) area ( p = 0.030) and fat-free mass (FFM; p = 0.023). There were significant group differences in concentrations of visfatin ( p = 0.020) and leptin ( p = 0.038) between the PLC and LEU groups. Visfatin displayed higher concentrations in the PLC group and leptin displayed higher concentrations in the LEU group. In addition, there were significant decreases in adiponectin concentrations for both groups (LEU: 652 ± 513 to 292 ± 447 pg·ml -1 ; PLC: 584 ± 572 to 245 ± 356 pg·ml -1 , p = 0.002) and MCP-1 only decreased in the PLC group (253 ± 119 to 206 ± 106 pg·ml -1 , p = 0.004). There were significant decreases in adiponectin concentrations in both groups and a decrease in MCP-1 concentrations in the PLC group. These decreases may be due to both adipokines possible relationship with VAT area. However, it is not known whether leucine has underlying properties that hinder changes in MCP-1 concentrations.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins Ovid Technologies</pub><pmid>38088883</pmid><doi>10.1519/JSC.0000000000004661</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-8326-5132</orcidid></addata></record> |
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subjects | Adipokines - pharmacology Adiponectin Adipose tissue Body Composition Dietary Supplements Dual energy X-ray absorptiometry Fat-free body mass Female Humans Leptin Leucine Leucine - pharmacology Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes Nicotinamide Phosphoribosyltransferase - pharmacology Perimenopause Physical training Placebos Post-menopause Postmenopause Resistance Training Strength training |
title | Effects of L-Leucine Supplementation and Resistance Training on Adipokine Markers in Untrained Perimenopausal and Postmenopausal Women |
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