Nickel-catalyzed regioselective hydrogen isotope exchange accelerated by 2-pyridones

Nickel-catalyzed regioselective hydrogen isotope exchange accelerated by 2-pyridones

A nickel-catalyzed hydrogen isotope exchange has been developed with acetone- as the deuterium source. The reaction showed an improved kinetic feature of H/D exchange under the assistance of 2-pyridones, efficiently affording regioselective labeled aryl and alkyl carboxamides.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2024-01, Vol.60 (4), p.384-387
Hauptverfasser: Jiang, Zhi-Jiang, Xu, Si-Han, Su, Yuhang, Hu, Erxun, Han, Jiawei, Bai, Jian-Fei, Tang, Bencan, Chen, Jia, Gao, Zhanghua
Format: Artikel
Sprache:eng
Schlagworte:
Deuterium
Exchanging
Hydrogen isotopes
Nickel
Regioselectivity
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Zusammenfassung:A nickel-catalyzed hydrogen isotope exchange has been developed with acetone- as the deuterium source. The reaction showed an improved kinetic feature of H/D exchange under the assistance of 2-pyridones, efficiently affording regioselective labeled aryl and alkyl carboxamides.
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc05257e