Fused‐Ring Pyrrole‐Based Near‐Infrared Emissive Organic RTP Material for Persistent Afterglow Bioimaging

Organic near‐infrared room temperature phosphorescence (RTP) materials offer remarkable advantages in bioimaging due to their characteristic time scales and background noise elimination. However, developing near‐infrared RTP materials for deep tissue imaging still faces challenges since the small ba...

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Veröffentlicht in:Angewandte Chemie International Edition 2024-01, Vol.63 (5), p.e202317431-n/a
Hauptverfasser: Zhao, Yeyun, Yang, Jianhui, Liang, Chao, Wang, Zhongjie, Zhang, Yongfeng, Li, Gengchen, Qu, Jiamin, Wang, Xi, Zhang, Yahui, Sun, Peng, Shi, Jianbing, Tong, Bin, Xie, Hai‐Yan, Cai, Zhengxu, Dong, Yuping
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Sprache:eng
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Zusammenfassung:Organic near‐infrared room temperature phosphorescence (RTP) materials offer remarkable advantages in bioimaging due to their characteristic time scales and background noise elimination. However, developing near‐infrared RTP materials for deep tissue imaging still faces challenges since the small band gap may increase the non‐radiative decay, resulting in weak emission and short phosphorescence lifetime. In this study, fused‐ring pyrrole‐based structures were employed as the guest molecules for the construction of long wavelength emissive RTP materials. Compared to the decrease of the singlet energy level, the triplet energy level showed a more effectively decrease with the increase of the conjugation of the substituent groups. Moreover, the sufficient conjugation of fused ring structures in the guest molecule suppresses the non‐radiative decay of triplet excitons. Therefore, a near‐infrared RTP material (764 nm) was achieved for deep penetration bioimaging. Tumor cell membrane is used to coat RTP nanoparticles (NPs) to avoid decreasing the RTP performance compared to traditional coating by amphiphilic surfactants. RTP NPs with tumor‐targeting properties show favorable phosphorescent properties, superior stability, and excellent biocompatibility. These NPs are applied for time‐resolved luminescence imaging to eliminate background interference with excellent tissue penetration. This study provides a practical solution to prepare long‐wavelength and long‐lifetime organic RTP materials and their applications in bioimaging. The development of room‐temperature phosphorescence (RTP) nano‐probes with long emission wavelength faces challenges. In this work, organic RTP materials with near‐infrared emission have been designed and cell membrane encapsulation has been used to optimize the nanomaterial process, achieving high signal‐to‐background ratio and imaging penetration depth.
ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.202317431