The OPTIFAST total and partial meal replacement programme reduces cardiometabolic risk in adults with obesity: Secondary and exploratory analysis of the OPTIWIN study

The OPTIFAST total and partial meal replacement programme reduces cardiometabolic risk in adults with obesity: Secondary and exploratory analysis of the OPTIWIN study

Aim The effects of weight loss with a partial or total meal replacement programme (MRP) on atherosclerotic cardiovascular disease (ASCVD) risk factors are not fully understood, in particular in people at higher CV risk. In the 52‐week randomized controlled OPTIWIN study in men and women with obesity...

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Veröffentlicht in:Diabetes, obesity & metabolism obesity & metabolism, 2024-03, Vol.26 (3), p.950-960
Hauptverfasser: Ard, Jamy D., Neeland, Ian J., Rothberg, Amy E., Chilton, Robert J., Luis, Daniel, Cohen, Sarah S., Johansen, Odd Erik
Format: Artikel
Sprache:eng
Schlagworte:
Age
Arteriosclerosis
Blood pressure
Body mass index
body weight
Body weight loss
caloric restriction
Cardiovascular diseases
clinical trial
Dietary restrictions
heart disease risk factors
Meals
Obesity
obesity management
Risk factors
Weight control
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Zusammenfassung:Aim The effects of weight loss with a partial or total meal replacement programme (MRP) on atherosclerotic cardiovascular disease (ASCVD) risk factors are not fully understood, in particular in people at higher CV risk. In the 52‐week randomized controlled OPTIWIN study in men and women with obesity, meal replacement programme (total for first 26 weeks, partial for the ensuing 26 weeks) with OPTIFAST (OP) resulted in significantly greater weight loss compared with a low‐calorie food‐based (FB) dietary plan, both as part of a comprehensive lifestyle intervention [OP (n = 135)/FB (n = 138) week 26: −12.4%/−6.0%, p 
ISSN:1462-8902
1463-1326
DOI:10.1111/dom.15392