Progressive Ataxia and Palatal Tremor Is Not Associated with IgLON5 Antibodies: Results From Two Cases

Progressive ataxia and palatal tremor (PAPT) and anti-IgLON5 disease share possible clinical presentations. Furthermore, both have been associated to a tauopathy mainly affecting the brainstem. Nonetheless, anti-IgLON5 antibodies have never been tested in PAPT. We report on two PAPT cases without ev...

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Veröffentlicht in:	Cerebellum (London, England) England), 2024-08, Vol.23 (4), p.1718-1721
Hauptverfasser:	Mastrangelo, Andrea, Giannoccaro, Maria Pia, Donadio, Vincenzo, Ricciardiello, Fortuna, Di Laudo, Felice, Palombo, Flavia, Liguori, Rocco, Rizzo, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antibodies Ataxia Ataxia - immunology Atrophy Autoantibodies - blood Biomedical and Life Sciences Biomedicine Brain stem Case Report Cell Adhesion Molecules, Neuronal - immunology Disease Electromyography Fainting Female Gait Humans Magnetic resonance imaging Male Medical history Melanoma Middle Aged Movement disorders Mutation Neurobiology Neurodegenerative diseases Neurology Neuropsychology Neurosciences Olives Patients Tau protein Tremor Tremor (Muscular contraction) Tremor - immunology
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Zusammenfassung:	Progressive ataxia and palatal tremor (PAPT) and anti-IgLON5 disease share possible clinical presentations. Furthermore, both have been associated to a tauopathy mainly affecting the brainstem. Nonetheless, anti-IgLON5 antibodies have never been tested in PAPT. We report on two PAPT cases without evidence of anti-IgLON5 antibodies in both CSF and serum. Despite common clinical and pathological characteristics, PAPT and IgLON5 disease are two distinct entities.
ISSN:	1473-4230 1473-4222 1473-4230
DOI:	10.1007/s12311-023-01647-w