Illuminating the understudied GPCR-ome

•GPCRs are targets of 30–40% of approved drugs.•There exist ∼100 orphan or understudied GPCRs which represent targets for new drug development.•Computational and structural approaches are accelerating the discovery of novel drugs for understudied GPCRS. G-protein-coupled receptors (GPCRs) are the ta...

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Veröffentlicht in:	Drug discovery today 2024-03, Vol.29 (3), p.103848-103848, Article 103848
Hauptverfasser:	Majumdar, Sreeparna, Chiu, Yi-Ting, Pickett, Julie E., Roth, Bryan L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Assay cell-based assays cryo-EM structures drug discovery high throughput screening Humans illuminating the druggable genome (IDG) Knock-in mice Ligands Mice molecular/chemical probes nanobody orphan GPCRs Receptors, G-Protein-Coupled - chemistry
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