Aging- and Alzheimer’s disease-related rare cell type dynamics in the mammalian brain unveiled

EasySci, a scalable single-cell profiling technique, uncovered over 300 mammalian brain cell states, revealing molecular features and dynamics of rare cell states linked to aging and Alzheimer’s disease. This work offers insights into cell states that expand (rare astrocytes and vascular leptomening...

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Veröffentlicht in:Nature genetics 2023-12, Vol.55 (12), p.2027-2028
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description EasySci, a scalable single-cell profiling technique, uncovered over 300 mammalian brain cell states, revealing molecular features and dynamics of rare cell states linked to aging and Alzheimer’s disease. This work offers insights into cell states that expand (rare astrocytes and vascular leptomeningeal cells in the olfactory bulb, reactive microglia, and oligodendrocytes) or are depleted (neuronal progenitors, neuroblasts and committed oligodendrocyte precursors) during normal and pathological aging.
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subjects 631/208/212
631/378
Aging
Agriculture
Alzheimer's disease
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
Brain research
Cancer Research
Cost analysis
CRISPR
Disease
Gene Function
Genomics
Human Genetics
Neurodegenerative diseases
Pathogenesis
Research Briefing
Signatures
Transcriptomes
title Aging- and Alzheimer’s disease-related rare cell type dynamics in the mammalian brain unveiled
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