Aging- and Alzheimer’s disease-related rare cell type dynamics in the mammalian brain unveiled
EasySci, a scalable single-cell profiling technique, uncovered over 300 mammalian brain cell states, revealing molecular features and dynamics of rare cell states linked to aging and Alzheimer’s disease. This work offers insights into cell states that expand (rare astrocytes and vascular leptomening...
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Veröffentlicht in: | Nature genetics 2023-12, Vol.55 (12), p.2027-2028 |
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description | EasySci, a scalable single-cell profiling technique, uncovered over 300 mammalian brain cell states, revealing molecular features and dynamics of rare cell states linked to aging and Alzheimer’s disease. This work offers insights into cell states that expand (rare astrocytes and vascular leptomeningeal cells in the olfactory bulb, reactive microglia, and oligodendrocytes) or are depleted (neuronal progenitors, neuroblasts and committed oligodendrocyte precursors) during normal and pathological aging. |
doi_str_mv | 10.1038/s41588-023-01573-x |
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subjects | 631/208/212 631/378 Aging Agriculture Alzheimer's disease Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Brain research Cancer Research Cost analysis CRISPR Disease Gene Function Genomics Human Genetics Neurodegenerative diseases Pathogenesis Research Briefing Signatures Transcriptomes |
title | Aging- and Alzheimer’s disease-related rare cell type dynamics in the mammalian brain unveiled |
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