Characterization of colorectal cancer by hierarchical clustering analyses of five immune cell markers

The present study analyzed the expression of five independent immunohistochemical markers, CD4, CD8, CD66b, CD68, and CD163, on immune cells within the colorectal cancer (CRC) tumor microenvironment (TME). Using hierarchical clustering, patients were successfully classified according to significant...

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Veröffentlicht in:	Pathology international 2024-01, Vol.74 (1), p.13-25
Hauptverfasser:	Ito, Sunao, Koshino, Akira, Komura, Masayuki, Kato, Shunsuke, Otani, Takahiro, Wang, Chengbo, Ueki, Akane, Takahashi, Hiroki, Ebi, Masahide, Ogasawara, Naotaka, Tsuzuki, Toyonori, Kasai, Kenji, Kasugai, Kunio, Takiguchi, Shuji, Takahashi, Satoru, Inaguma, Shingo
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer CD163 antigen CD4 antigen CD47 CD8 antigen Cluster analysis Clustering Colorectal cancer Colorectal carcinoma Hazard identification Health hazards hierarchical clustering analysis Immune checkpoint Immune system immunohistochemistry Mismatch repair mismatch repair‐proficient CRC PD-L1 protein PD‐L1 Phagocytosis Risk factors Statistical models Survival Tumor cells Tumor microenvironment Tumors
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Zusammenfassung:	The present study analyzed the expression of five independent immunohistochemical markers, CD4, CD8, CD66b, CD68, and CD163, on immune cells within the colorectal cancer (CRC) tumor microenvironment (TME). Using hierarchical clustering, patients were successfully classified according to significant associations with clinicopathological features and/or survival. Patients with mismatch repair‐proficient (pMMR) CRC were categorized into four groups with survival differences (p = 0.0084): CD4Low, CD4High, MΦHigh, and CD8Low. MΦHigh tumors showed significantly higher expression of CD47 (p
ISSN:	1320-5463 1440-1827
DOI:	10.1111/pin.13391