Effects of Processing Parameters on the Morphology and Size of Electrospun PHBV Micro- and Nano-Fibers
Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) was used to fabricate micro- and nano-fibrous, non-woven mats by electrospinning for potential tissue engineering applications. The morphology and size of electrospun fibers were assessed systematically by varying the processing parameters. It was...
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Veröffentlicht in: | Key engineering materials 2007-03, Vol.334-335, p.1233-1236 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) was used to fabricate micro- and
nano-fibrous, non-woven mats by electrospinning for potential tissue engineering applications. The
morphology and size of electrospun fibers were assessed systematically by varying the processing
parameters. It was found that the diameter of the fibers produced generally increased with
electrospinning voltage, needle diameter for the polymer jet and polymer solution concentration.
Beaded fibers were readily produced at low PHBV concentrations, whereas the needle was blocked
within a very short time during electrospinning when the PHBV concentration was too high. At the
polymer concentration of 7.5 % w/v, it was shown that beadless PHBV fibers could be generated
continuously by adjusting the electrospinning parameters to appropriate values. This study has clearly
demonstrated that electrospinning can be an effective technique to produce PHBV micro- and
nano-fibers. It has also been shown that composite fibers containing hydroxyapatite (HA) can be
produced using the electrospinning technique. |
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ISSN: | 1013-9826 1662-9795 1662-9795 |
DOI: | 10.4028/www.scientific.net/KEM.334-335.1233 |