Effects of Processing Parameters on the Morphology and Size of Electrospun PHBV Micro- and Nano-Fibers

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) was used to fabricate micro- and nano-fibrous, non-woven mats by electrospinning for potential tissue engineering applications. The morphology and size of electrospun fibers were assessed systematically by varying the processing parameters. It was...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Key engineering materials 2007-03, Vol.334-335, p.1233-1236
Hauptverfasser: Tong, Ho Wang, Wang, Min
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) was used to fabricate micro- and nano-fibrous, non-woven mats by electrospinning for potential tissue engineering applications. The morphology and size of electrospun fibers were assessed systematically by varying the processing parameters. It was found that the diameter of the fibers produced generally increased with electrospinning voltage, needle diameter for the polymer jet and polymer solution concentration. Beaded fibers were readily produced at low PHBV concentrations, whereas the needle was blocked within a very short time during electrospinning when the PHBV concentration was too high. At the polymer concentration of 7.5 % w/v, it was shown that beadless PHBV fibers could be generated continuously by adjusting the electrospinning parameters to appropriate values. This study has clearly demonstrated that electrospinning can be an effective technique to produce PHBV micro- and nano-fibers. It has also been shown that composite fibers containing hydroxyapatite (HA) can be produced using the electrospinning technique.
ISSN:1013-9826
1662-9795
1662-9795
DOI:10.4028/www.scientific.net/KEM.334-335.1233