Relay Copper-Catalyzed Synthesis of Imidazo[1,5‑a]pyridine Scaffolds from Phenylalanine and Halohydrocarbon

An efficient and straightforward strategy to synthesize imidazo­[1,5-a]­pyridine compounds from phenylalanine and halohydrocarbon has been successfully developed. The protocol features a relay copper-catalyzed reaction involving intermolecular C–O coupling and intramolecular C–N cyclization, providing an approach to access a diverse range of imidazo­[1,5-a]­pyridine derivatives with unique aza quaternary carbon centers.