Deep learning enables time-efficient soft tissue enhancement in CBCT: Proof-of-concept study for dentomaxillofacial applications

•Deep learning provides effective and time-efficient noise reduction in CBCT.•The developed deep learning methods generalized well to previously unseen data.•Deep learning improved soft tissue visibility compared to conventional algorithm Deep learning denoising may expand the clinical utility of CBCT. The use of iterative and deep learning reconstruction methods, which would allow effective noise reduction, is limited in cone-beam computed tomography (CBCT). As a consequence, the visibility of soft tissues is limited with CBCT. The study aimed to improve this issue through time-efficient deep learning enhancement (DLE) methods. Two DLE networks, UNIT and U-Net, were trained with simulated CBCT data. The performance of the networks was tested with three different test data sets. The quantitative evaluation measured the structural similarity index measure (SSIM) and the peak signal-to-noise ratio (PSNR) of the DLE reconstructions with respect to the ground truth iterative reconstruction method. In the second assessment, a dentomaxillofacial radiologist assessed the resolution of hard tissue structures, visibility of soft tissues, and overall image quality of real patient data using the Likert scale. Finally, the technical image quality was determined using modulation transfer function, noise power spectrum, and noise magnitude analyses. The study demonstrated that deep learning CBCT denoising is feasible and time efficient. The DLE methods, trained with simulated CBCT data, generalized well, and DLE provided quantitatively (SSIM/PSNR) and visually similar noise-reduction as conventional IR, but with faster processing time. The DLE methods improved soft tissue visibility compared to the conventional Feldkamp-Davis-Kress (FDK) algorithm through noise reduction. However, in hard tissue quantification tasks, the radiologist preferred the FDK over the DLE methods. Post-reconstruction DLE allowed feasible reconstruction times while yielding improvements in soft tissue visibility in each dataset.