Synthesis of N -substituted phthalimides via Pd-catalyzed [4+1] cycloaddition reaction

Synthesis of N -substituted phthalimides via Pd-catalyzed [4+1] cycloaddition reaction

A novel Pd-catalyzed assembly of -substituted phthalimides by merging of [4+1] cycloaddition and difluorocarbene transfer carbonylation from 2-iodo- -phenylbenzamides and difluorocarbene precursors is disclosed. Difluorocarbene acts as a carbonyl source and simultaneously forms one C-C bond, one C-N...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2023-12, Vol.59 (100), p.14839-14842
Hauptverfasser: Hu, Chengxian, Wang, Lu, Wu, Yuanyuan, Zheng, Yonglong, Fu, Ying, Du, Zhengyin
Format: Artikel
Sprache:eng
Schlagworte:
Carbonyls
Chemical synthesis
Covalent bonds
Cycloaddition
Phthalimides
Substitutes
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Beschreibung
Zusammenfassung:A novel Pd-catalyzed assembly of -substituted phthalimides by merging of [4+1] cycloaddition and difluorocarbene transfer carbonylation from 2-iodo- -phenylbenzamides and difluorocarbene precursors is disclosed. Difluorocarbene acts as a carbonyl source and simultaneously forms one C-C bond, one C-N bond and one CO bond to produce -substituted phthalimides in high yields.
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc04534j