Challenges in recombinant brain-derived neurotrophic factor production
Brain-derived neurotrophic factor (BDNF) is a neurotrophin of marked commercial, scientific, diagnostic, and therapeutic interest. The preservation of its structural cystine-knot is the main challenge in its industrial production. A suitable expression system is critical to achieve the most efficien...
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| Veröffentlicht in: | Trends in biotechnology (Regular ed.) 2024-05, Vol.42 (5), p.522-525 |
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| creator | Rodrigues, Éllen F. Fachin, Ana L. Marins, Mozart Stabeli, Rodrigo G. Beleboni, Renê O. |
| description | Brain-derived neurotrophic factor (BDNF) is a neurotrophin of marked commercial, scientific, diagnostic, and therapeutic interest. The preservation of its structural cystine-knot is the main challenge in its industrial production. A suitable expression system is critical to achieve the most efficient production of bioactive and stable BDNF for pharmaceutical purposes.
Brain-derived neurotrophic factor (BDNF) is a neurotrophin of marked commercial, scientific, diagnostic, and therapeutic interest. The preservation of its structural cystine-knot is the main challenge in its industrial production. A suitable expression system is critical to achieve the most efficient production of bioactive and stable BDNF for pharmaceutical purposes. |
| doi_str_mv | 10.1016/j.tibtech.2023.11.003 |
| format | Article |
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Brain-derived neurotrophic factor (BDNF) is a neurotrophin of marked commercial, scientific, diagnostic, and therapeutic interest. The preservation of its structural cystine-knot is the main challenge in its industrial production. A suitable expression system is critical to achieve the most efficient production of bioactive and stable BDNF for pharmaceutical purposes.</description><identifier>ISSN: 0167-7799</identifier><identifier>ISSN: 1879-3096</identifier><identifier>EISSN: 1879-3096</identifier><identifier>DOI: 10.1016/j.tibtech.2023.11.003</identifier><identifier>PMID: 38008688</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Amino acids ; Animals ; Biological activity ; biotechnology ; Brain ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - genetics ; Brain-Derived Neurotrophic Factor - metabolism ; Cell culture ; Chemical bonds ; E coli ; expression systems ; Humans ; Industrial production ; Medical prognosis ; neurotrophins ; pharmaceutical biotechnology ; Pharmaceuticals ; Production costs ; production economics ; Protein expression ; Protein folding ; recombinant proteins ; Recombinant Proteins - chemistry ; Recombinant Proteins - genetics ; Recombinant Proteins - metabolism ; therapeutics ; Toxicity ; Yeast</subject><ispartof>Trends in biotechnology (Regular ed.), 2024-05, Vol.42 (5), p.522-525</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><rights>2023. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c374t-c3ba63b24a49d5297001a0260d2fb645016e0ddea73bc924a5a966c005e15caf3</cites><orcidid>0000-0002-1289-9688 ; 0000-0001-8407-8865 ; 0000-0001-7389-4023 ; 0000-0001-8755-9250 ; 0000-0002-0476-920X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/3049722684?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38008688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodrigues, Éllen F.</creatorcontrib><creatorcontrib>Fachin, Ana L.</creatorcontrib><creatorcontrib>Marins, Mozart</creatorcontrib><creatorcontrib>Stabeli, Rodrigo G.</creatorcontrib><creatorcontrib>Beleboni, Renê O.</creatorcontrib><title>Challenges in recombinant brain-derived neurotrophic factor production</title><title>Trends in biotechnology (Regular ed.)</title><addtitle>Trends Biotechnol</addtitle><description>Brain-derived neurotrophic factor (BDNF) is a neurotrophin of marked commercial, scientific, diagnostic, and therapeutic interest. The preservation of its structural cystine-knot is the main challenge in its industrial production. A suitable expression system is critical to achieve the most efficient production of bioactive and stable BDNF for pharmaceutical purposes.
Brain-derived neurotrophic factor (BDNF) is a neurotrophin of marked commercial, scientific, diagnostic, and therapeutic interest. The preservation of its structural cystine-knot is the main challenge in its industrial production. A suitable expression system is critical to achieve the most efficient production of bioactive and stable BDNF for pharmaceutical purposes.</description><subject>Amino acids</subject><subject>Animals</subject><subject>Biological activity</subject><subject>biotechnology</subject><subject>Brain</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>Cell culture</subject><subject>Chemical bonds</subject><subject>E coli</subject><subject>expression systems</subject><subject>Humans</subject><subject>Industrial production</subject><subject>Medical prognosis</subject><subject>neurotrophins</subject><subject>pharmaceutical biotechnology</subject><subject>Pharmaceuticals</subject><subject>Production costs</subject><subject>production economics</subject><subject>Protein expression</subject><subject>Protein folding</subject><subject>recombinant 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The preservation of its structural cystine-knot is the main challenge in its industrial production. A suitable expression system is critical to achieve the most efficient production of bioactive and stable BDNF for pharmaceutical purposes.
Brain-derived neurotrophic factor (BDNF) is a neurotrophin of marked commercial, scientific, diagnostic, and therapeutic interest. The preservation of its structural cystine-knot is the main challenge in its industrial production. A suitable expression system is critical to achieve the most efficient production of bioactive and stable BDNF for pharmaceutical purposes.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38008688</pmid><doi>10.1016/j.tibtech.2023.11.003</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-1289-9688</orcidid><orcidid>https://orcid.org/0000-0001-8407-8865</orcidid><orcidid>https://orcid.org/0000-0001-7389-4023</orcidid><orcidid>https://orcid.org/0000-0001-8755-9250</orcidid><orcidid>https://orcid.org/0000-0002-0476-920X</orcidid></addata></record> |
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| subjects | Amino acids Animals Biological activity biotechnology Brain Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Cell culture Chemical bonds E coli expression systems Humans Industrial production Medical prognosis neurotrophins pharmaceutical biotechnology Pharmaceuticals Production costs production economics Protein expression Protein folding recombinant proteins Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism therapeutics Toxicity Yeast |
| title | Challenges in recombinant brain-derived neurotrophic factor production |
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