Challenges in recombinant brain-derived neurotrophic factor production

Brain-derived neurotrophic factor (BDNF) is a neurotrophin of marked commercial, scientific, diagnostic, and therapeutic interest. The preservation of its structural cystine-knot is the main challenge in its industrial production. A suitable expression system is critical to achieve the most efficien...

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Veröffentlicht in:	Trends in biotechnology (Regular ed.) 2024-05, Vol.42 (5), p.522-525
Hauptverfasser:	Rodrigues, Éllen F., Fachin, Ana L., Marins, Mozart, Stabeli, Rodrigo G., Beleboni, Renê O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Biological activity Brain Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Cell culture Chemical bonds E coli expression systems Humans Industrial production Medical prognosis pharmaceutical biotechnology Pharmaceuticals Production costs Protein expression Protein folding recombinant proteins Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Toxicity Yeast
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Beschreibung
Zusammenfassung:	Brain-derived neurotrophic factor (BDNF) is a neurotrophin of marked commercial, scientific, diagnostic, and therapeutic interest. The preservation of its structural cystine-knot is the main challenge in its industrial production. A suitable expression system is critical to achieve the most efficient production of bioactive and stable BDNF for pharmaceutical purposes. Brain-derived neurotrophic factor (BDNF) is a neurotrophin of marked commercial, scientific, diagnostic, and therapeutic interest. The preservation of its structural cystine-knot is the main challenge in its industrial production. A suitable expression system is critical to achieve the most efficient production of bioactive and stable BDNF for pharmaceutical purposes.
ISSN:	0167-7799 1879-3096 1879-3096
DOI:	10.1016/j.tibtech.2023.11.003