Uncovering personal circadian responses to light through particle swarm optimization

•Particle swarm optimization can uncover personal Kronauer's model parameters.•Initial conditions are simultaneously optimised in a 6-dimensional scheme.•Optimization can be performed under regular or irregular schedules such as jet-lag.•Personalization of circadian response to light could improve light therapies. Kronauer's oscillator model of the human central pacemaker is one of the most commonly used approaches to study the human circadian response to light. Two sources of error when applying it to a personal light exposure have been identified: (1) as a populational model, it does not consider inter-individual variability, and (2) the initial conditions needed to integrate the model are usually unknown, and thus subjectively estimated. In this work, we evaluate the ability of particle swarm optimization (PSO) algorithms to simultaneously uncover the optimal initial conditions and individual parameters of a pre-defined Kronauer's oscillator model. A Canonical PSO, a Dynamic Multi-Swarm PSO and a novel modification of the latter, namely Hierarchical Dynamic Multi-Swarm PSO, are evaluated. Two different target models (under a regular and an irregular schedule) are defined, and the same realistic light profile is fed to them. Based on their output, a fitness function is proposed, which is minimized by the algorithms to find the optimum set of parameters and initial conditions of the model. We demonstrate that Dynamic Multi-Swarm and Hierarchical Dynamic Multi-Swarm algorithms can accurately uncover personal circadian parameters under both regular and irregular schedules, but as expected, optimization is easier under a regular schedule. Circadian parameters play the most important role in the optimization process and should be prioritized over initial conditions, although assessment of the impact of misestimating the latter is recommended. The log-log linear relationship between mean absolute error and computational cost shows that the number of particles to use is at the discretion of the user. The robustness and low errors achieved by the algorithms support their further testing, validation and systematic application to empirical data under a regular or irregular schedule. Uncovering personal circadian parameters can improve the assessment of the circadian status of a person and the applicability of personalized light therapies, as well as help to discover other factors that may lie behind the interindividual variability in the circadian response to ligh