Customizable miniaturized SPR instrument

Prism-based surface Plasmon resonance (SPR) system, as one of the leading candidate concepts for scale application and commercial solution, has good stability, high-sensitivity and greater theoretical/technical maturity. Therefore, to take advantage of prism-based SPR system fully, and break up limitations of complicated and bulky traditional prism-based SPR system, optimal and compact design of optical system is an effective solution. Herein, a customizable miniaturized prism-based SPR system is developed by optical system optimization and integrated design, combining portable data acquisition and processing technology (FPGA-based multifunctional data processing). This proposed prism-based SPR system can achieve a miniaturized SPR system, thus, it also can meet the requirements of flexibility configuration and customizable performance to accommodate the various needs of different users and application scenes. Additionally, the customizable features can make it to achieve the best performance optimization and differentiation. [Display omitted] •A customizable miniaturized prism-based SPR instrument is developed.•The portable data acquisition and processing technology (FPGA-based multifunctional data processing) is adopted.•This proposed SPR system has flexibility configuration and customizable performance.•The average refractive index sensitivity is 27959 pixel/RIU.•The measurement error caused by resonant pixel fluctuation is lower than 0.061 % RIU.