POLQ to the rescue for double-strand break repair during mitosis

DNA polymerase θ (POLQ) repairs mitotic DNA breaks; this requires RHINO and PLK1, averts genomic instability and may underlie effects of POLQ inhibitors in HDR-deficient cancer cells. We discuss recent work on mitotic DNA break processing and repair, the need for multiple DSB repair pathways and imp...

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Veröffentlicht in:	Nature structural & molecular biology 2023-12, Vol.30 (12), p.1828-1830
Hauptverfasser:	van Vugt, Marcel A. T. M., Tijsterman, Marcel
Format:	Artikel
Sprache:	eng
Schlagworte:	14 14/1 631/337/1427/2122 631/80/641/1655 Biochemistry Biological Microscopy Biomedical and Life Sciences Cancer Cell cycle Chromosomes Comment Cyclin-dependent kinases Deoxyribonucleic acid DNA DNA damage DNA polymerase DNA Repair DNA-directed DNA polymerase DNA-Directed DNA Polymerase - metabolism Double-strand break repair Genomes Genomic instability Kinases Life Sciences Membrane Biology Mitosis Molecular biology Phosphorylation Physiology Polo-like kinase 1 Protein Structure Yeast
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Zusammenfassung:	DNA polymerase θ (POLQ) repairs mitotic DNA breaks; this requires RHINO and PLK1, averts genomic instability and may underlie effects of POLQ inhibitors in HDR-deficient cancer cells. We discuss recent work on mitotic DNA break processing and repair, the need for multiple DSB repair pathways and implications of therapeutic POLQ targeting in cancer.
ISSN:	1545-9993 1545-9985
DOI:	10.1038/s41594-023-01168-4