Emerging perspectives: unraveling the anticancer potential of vitamin D3
Vitamin D 3 , a fat-soluble vitamin known for its critical function in calcium homeostasis and bone health, is gaining interest for its anticancer properties. Observational studies have suggested a negative relationship between vitamin D levels and the incidence of some malignancies throughout the y...
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Veröffentlicht in: | Naunyn-Schmiedeberg's archives of pharmacology 2024-05, Vol.397 (5), p.2877-2933 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Vitamin D
3
, a fat-soluble vitamin known for its critical function in calcium homeostasis and bone health, is gaining interest for its anticancer properties. Observational studies have suggested a negative relationship between vitamin D levels and the incidence of some malignancies throughout the years, prompting substantial investigation to find its anticancer effects. The purpose of this comprehensive review is to investigate the diverse function of vitamin D
3
in cancer prevention and therapy. We explored the molecular mechanism underlying its effects on cancer cells, which range from cell cycle control and death to angiogenesis and immune response modulation. Insights from in vitro and in vivo studies provide valuable evidence supporting its anticancer potential. Furthermore, we look at epidemiological and clinical studies that investigate the relationship between vitamin D
3
levels and cancer risk or treatment results. Vitamin D
3
supplementation’s safety profile and cost-effectiveness increase its attractiveness as an adjuvant therapy in conjunction with traditional treatment regimens. Our critical review of the current literature provides an in-depth understanding of vitamin D
3
’s anticancer effect, covering the obstacles and possibilities in realizing its promise for cancer prevention and therapy. The findings of this study might pave the way for the development of innovative treatment techniques that take use of the advantages of vitamin D
3
to fight cancer and improve patient care. As research progresses, a better understanding of vitamin D
3
’s anticancer processes will surely simplify its incorporation into personalized cancer care techniques, hence enhancing patient outcomes in the battle against cancer. |
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ISSN: | 0028-1298 1432-1912 1432-1912 |
DOI: | 10.1007/s00210-023-02819-5 |