The role of Ca2+-signaling in the regulation of epigenetic mechanisms

Epigenetic mechanisms regulate multiple cell functions like gene expression and chromatin conformation and stability, and its misregulation could lead to several diseases including cancer. Epigenetic drugs are currently under investigation in a broad range of diseases, but the cellular processes inv...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cell calcium (Edinburgh) 2024-01, Vol.117, p.102836-102836, Article 102836
Hauptverfasser: Hernández-Oliveras, Andrés, Zarain-Herzberg, Angel
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 102836
container_issue
container_start_page 102836
container_title Cell calcium (Edinburgh)
container_volume 117
creator Hernández-Oliveras, Andrés
Zarain-Herzberg, Angel
description Epigenetic mechanisms regulate multiple cell functions like gene expression and chromatin conformation and stability, and its misregulation could lead to several diseases including cancer. Epigenetic drugs are currently under investigation in a broad range of diseases, but the cellular processes involved in regulating epigenetic mechanisms are not fully understood. Calcium (Ca2+) signaling regulates several cellular mechanisms such as proliferation, gene expression, and metabolism, among others. Moreover, Ca2+ signaling is also involved in diseases such as neurological disorders, cardiac, and cancer. Evidence indicates that Ca2+ signaling and epigenetics are involved in the same cellular functions, which suggests a possible interplay between both mechanisms. Ca2+-activated transcription factors regulate the recruitment of chromatin remodeling complexes into their target genes, and Ca2+-sensing proteins modulate their activity and intracellular localization. Thus, Ca2+ signaling is an important regulator of epigenetic mechanisms. Moreover, Ca2+ signaling activates epigenetic mechanisms that in turn regulate genes involved in Ca2+ signaling, suggesting possible feedback between both mechanisms. The understanding of how epigenetics are regulated could lead to developing better therapeutical approaches.
doi_str_mv 10.1016/j.ceca.2023.102836
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2892661204</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2892661204</sourcerecordid><originalsourceid>FETCH-LOGICAL-c210t-d5813e43675b20cfbea7b217c270da1c6e88ec594088a72a44d89a12d34705bf3</originalsourceid><addsrcrecordid>eNotkE1Lw0AURQdRsFb_gKssBUl9780kmSyl1A8ouKnrYTJ5Sackk5pJF_57G-rqwr2HuzhCPCKsEDB_OawcO7siIHkuSMv8Siwwk5RiWeK1WAAqmSrM4VbcxXgAgFIWuBCb3Z6Tceg4GZpkbek5jb4NtvOhTXxIpnnl9tTZyQ9hZvjoWw48eZf07PY2-NjHe3HT2C7yw38uxffbZrf-SLdf75_r123qCGFK60yjZCXzIqsIXFOxLSrCwlEBtUWXs9bsslKB1rYgq1StS4tUS1VAVjVyKZ4uv8dx-DlxnEzvo-Ous4GHUzSkS8pzJFBnlC6oG4cYR27McfS9HX8NgpmdmYOZnZnZmbk4k3_VIV9D</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2892661204</pqid></control><display><type>article</type><title>The role of Ca2+-signaling in the regulation of epigenetic mechanisms</title><source>Access via ScienceDirect (Elsevier)</source><creator>Hernández-Oliveras, Andrés ; Zarain-Herzberg, Angel</creator><creatorcontrib>Hernández-Oliveras, Andrés ; Zarain-Herzberg, Angel</creatorcontrib><description>Epigenetic mechanisms regulate multiple cell functions like gene expression and chromatin conformation and stability, and its misregulation could lead to several diseases including cancer. Epigenetic drugs are currently under investigation in a broad range of diseases, but the cellular processes involved in regulating epigenetic mechanisms are not fully understood. Calcium (Ca2+) signaling regulates several cellular mechanisms such as proliferation, gene expression, and metabolism, among others. Moreover, Ca2+ signaling is also involved in diseases such as neurological disorders, cardiac, and cancer. Evidence indicates that Ca2+ signaling and epigenetics are involved in the same cellular functions, which suggests a possible interplay between both mechanisms. Ca2+-activated transcription factors regulate the recruitment of chromatin remodeling complexes into their target genes, and Ca2+-sensing proteins modulate their activity and intracellular localization. Thus, Ca2+ signaling is an important regulator of epigenetic mechanisms. Moreover, Ca2+ signaling activates epigenetic mechanisms that in turn regulate genes involved in Ca2+ signaling, suggesting possible feedback between both mechanisms. The understanding of how epigenetics are regulated could lead to developing better therapeutical approaches.</description><identifier>ISSN: 0143-4160</identifier><identifier>EISSN: 1532-1991</identifier><identifier>DOI: 10.1016/j.ceca.2023.102836</identifier><language>eng</language><ispartof>Cell calcium (Edinburgh), 2024-01, Vol.117, p.102836-102836, Article 102836</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c210t-d5813e43675b20cfbea7b217c270da1c6e88ec594088a72a44d89a12d34705bf3</citedby><cites>FETCH-LOGICAL-c210t-d5813e43675b20cfbea7b217c270da1c6e88ec594088a72a44d89a12d34705bf3</cites><orcidid>0000-0002-1916-4780</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Hernández-Oliveras, Andrés</creatorcontrib><creatorcontrib>Zarain-Herzberg, Angel</creatorcontrib><title>The role of Ca2+-signaling in the regulation of epigenetic mechanisms</title><title>Cell calcium (Edinburgh)</title><description>Epigenetic mechanisms regulate multiple cell functions like gene expression and chromatin conformation and stability, and its misregulation could lead to several diseases including cancer. Epigenetic drugs are currently under investigation in a broad range of diseases, but the cellular processes involved in regulating epigenetic mechanisms are not fully understood. Calcium (Ca2+) signaling regulates several cellular mechanisms such as proliferation, gene expression, and metabolism, among others. Moreover, Ca2+ signaling is also involved in diseases such as neurological disorders, cardiac, and cancer. Evidence indicates that Ca2+ signaling and epigenetics are involved in the same cellular functions, which suggests a possible interplay between both mechanisms. Ca2+-activated transcription factors regulate the recruitment of chromatin remodeling complexes into their target genes, and Ca2+-sensing proteins modulate their activity and intracellular localization. Thus, Ca2+ signaling is an important regulator of epigenetic mechanisms. Moreover, Ca2+ signaling activates epigenetic mechanisms that in turn regulate genes involved in Ca2+ signaling, suggesting possible feedback between both mechanisms. The understanding of how epigenetics are regulated could lead to developing better therapeutical approaches.</description><issn>0143-4160</issn><issn>1532-1991</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNotkE1Lw0AURQdRsFb_gKssBUl9780kmSyl1A8ouKnrYTJ5Sackk5pJF_57G-rqwr2HuzhCPCKsEDB_OawcO7siIHkuSMv8Siwwk5RiWeK1WAAqmSrM4VbcxXgAgFIWuBCb3Z6Tceg4GZpkbek5jb4NtvOhTXxIpnnl9tTZyQ9hZvjoWw48eZf07PY2-NjHe3HT2C7yw38uxffbZrf-SLdf75_r123qCGFK60yjZCXzIqsIXFOxLSrCwlEBtUWXs9bsslKB1rYgq1StS4tUS1VAVjVyKZ4uv8dx-DlxnEzvo-Ous4GHUzSkS8pzJFBnlC6oG4cYR27McfS9HX8NgpmdmYOZnZnZmbk4k3_VIV9D</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Hernández-Oliveras, Andrés</creator><creator>Zarain-Herzberg, Angel</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1916-4780</orcidid></search><sort><creationdate>202401</creationdate><title>The role of Ca2+-signaling in the regulation of epigenetic mechanisms</title><author>Hernández-Oliveras, Andrés ; Zarain-Herzberg, Angel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c210t-d5813e43675b20cfbea7b217c270da1c6e88ec594088a72a44d89a12d34705bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hernández-Oliveras, Andrés</creatorcontrib><creatorcontrib>Zarain-Herzberg, Angel</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cell calcium (Edinburgh)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hernández-Oliveras, Andrés</au><au>Zarain-Herzberg, Angel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of Ca2+-signaling in the regulation of epigenetic mechanisms</atitle><jtitle>Cell calcium (Edinburgh)</jtitle><date>2024-01</date><risdate>2024</risdate><volume>117</volume><spage>102836</spage><epage>102836</epage><pages>102836-102836</pages><artnum>102836</artnum><issn>0143-4160</issn><eissn>1532-1991</eissn><abstract>Epigenetic mechanisms regulate multiple cell functions like gene expression and chromatin conformation and stability, and its misregulation could lead to several diseases including cancer. Epigenetic drugs are currently under investigation in a broad range of diseases, but the cellular processes involved in regulating epigenetic mechanisms are not fully understood. Calcium (Ca2+) signaling regulates several cellular mechanisms such as proliferation, gene expression, and metabolism, among others. Moreover, Ca2+ signaling is also involved in diseases such as neurological disorders, cardiac, and cancer. Evidence indicates that Ca2+ signaling and epigenetics are involved in the same cellular functions, which suggests a possible interplay between both mechanisms. Ca2+-activated transcription factors regulate the recruitment of chromatin remodeling complexes into their target genes, and Ca2+-sensing proteins modulate their activity and intracellular localization. Thus, Ca2+ signaling is an important regulator of epigenetic mechanisms. Moreover, Ca2+ signaling activates epigenetic mechanisms that in turn regulate genes involved in Ca2+ signaling, suggesting possible feedback between both mechanisms. The understanding of how epigenetics are regulated could lead to developing better therapeutical approaches.</abstract><doi>10.1016/j.ceca.2023.102836</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-1916-4780</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0143-4160
ispartof Cell calcium (Edinburgh), 2024-01, Vol.117, p.102836-102836, Article 102836
issn 0143-4160
1532-1991
language eng
recordid cdi_proquest_miscellaneous_2892661204
source Access via ScienceDirect (Elsevier)
title The role of Ca2+-signaling in the regulation of epigenetic mechanisms
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T17%3A32%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20Ca2+-signaling%20in%20the%20regulation%20of%20epigenetic%20mechanisms&rft.jtitle=Cell%20calcium%20(Edinburgh)&rft.au=Hern%C3%A1ndez-Oliveras,%20Andr%C3%A9s&rft.date=2024-01&rft.volume=117&rft.spage=102836&rft.epage=102836&rft.pages=102836-102836&rft.artnum=102836&rft.issn=0143-4160&rft.eissn=1532-1991&rft_id=info:doi/10.1016/j.ceca.2023.102836&rft_dat=%3Cproquest_cross%3E2892661204%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2892661204&rft_id=info:pmid/&rfr_iscdi=true