Effect of Glutamate Antibody F(ab)2 Fragments on Memory Changes in Aged C57BL/6 Mice

Intranasal administration of F(ab)2 fragments of anti-glutamate antibodies to 12-month-old C57BL/6 mice improves passive avoidance conditioning and have no effect on horizontal and vertical locomotor activity in the open-field test. In contrast to full-length antibodies to glutamate, their F(ab)2 fr...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2023-10, Vol.175 (6), p.762-764
Hauptverfasser:	Davydova, T. V., Vetrile, L. A., Zakharova, I. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Antibodies Antigens Biological products Biomedical and Life Sciences Biomedicine Cell Biology Drug dosages Experiments Fab Glutamate Internal Medicine Intranasal administration Laboratory Medicine Locomotor activity Medical research Memory Mice Nervous system diseases Neurosciences Open-field behavior Pathology Physiology Proteins Viral antibodies
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Zusammenfassung:	Intranasal administration of F(ab)2 fragments of anti-glutamate antibodies to 12-month-old C57BL/6 mice improves passive avoidance conditioning and have no effect on horizontal and vertical locomotor activity in the open-field test. In contrast to full-length antibodies to glutamate, their F(ab)2 fragments significantly increase the number of animals developed a conditioned passive avoidance reflex.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-023-05941-9