Genome‐wide search reveals the uniqueness of DNA regions associated with coat color and innate immunity in Hokkaido Native Horse

Genome‐wide search reveals the uniqueness of DNA regions associated with coat color and innate immunity in Hokkaido Native Horse

Hokkaido Native Horse (HKD) is a horse breed native to Hokkaido in Japan known for the traits such as coat color with no white spots and adaptability to the local cold climate. To examine whether those traits of HKD are conferred at the DNA level, we attempted to identify fixed DNA regions in HKD in...

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Veröffentlicht in:Animal science journal 2023-01, Vol.94 (1), p.e13884-n/a
Hauptverfasser: Amano, Tomoko, Yokawa, Haruhi, Masuda, Yutaka, Tozaki, Teruaki, Kawai, Masahito, Shirai, Kouichi
Format: Artikel
Sprache:eng
Schlagworte:
Adaptability
Cluster analysis
Color
Coloration
Deoxyribonucleic acid
DNA
Gene polymorphism
Genomes
Genotypes
Hokkaido Native Horse
Homozygosity
Innate immunity
Nucleotides
Polymorphism
Principal components analysis
selection signature
Signatures
Single-nucleotide polymorphism
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Zusammenfassung:Hokkaido Native Horse (HKD) is a horse breed native to Hokkaido in Japan known for the traits such as coat color with no white spots and adaptability to the local cold climate. To examine whether those traits of HKD are conferred at the DNA level, we attempted to identify fixed DNA regions in HKD individuals, that is, the selection signatures of HKD. A comparison of genome‐wide single nucleotide polymorphism genotypes in 58 HKD individuals by principal component analysis, and cluster analysis between breeds, including HKD, and within the HKD individuals indicated the genetic independence of HKD as a breed. Tajima's D analysis and runs of homozygosity analysis identified 23 selection signatures unique to HKD (P 
ISSN:1344-3941
1740-0929
DOI:10.1111/asj.13884