Sex Differences In Patients With Primary Hyperparathyroidism

Sex Differences In Patients With Primary Hyperparathyroidism

Differences in presenting symptoms of PHPT and outcomes of parathyroidectomy (PTX) between sexes has been described, but whether these can be assessed by perioperative use of a validated tool, such as the Pasieka Parathyroidectomy Assessment Score (PAS), is unknown. All PHPT patients were asked to c...

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Veröffentlicht in:Surgery 2024-01, Vol.175 (1), p.65-72
Hauptverfasser: Baugh, Katherine A., Liu, Jason B., Yip, Linwah, McCoy, Kelly L., Carty, Sally E., Ramonell, Kimberly M.
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container_end_page 72
container_issue 1
container_start_page 65
container_title Surgery
container_volume 175
creator Baugh, Katherine A.
Liu, Jason B.
Yip, Linwah
McCoy, Kelly L.
Carty, Sally E.
Ramonell, Kimberly M.
description Differences in presenting symptoms of PHPT and outcomes of parathyroidectomy (PTX) between sexes has been described, but whether these can be assessed by perioperative use of a validated tool, such as the Pasieka Parathyroidectomy Assessment Score (PAS), is unknown. All PHPT patients were asked to complete symptom assessment at the preoperative and postoperative visits. The assessment included query for 13 PAS parameters evaluated using a visual analog-scale as described by Pasieka (summative score 0-1300), and general quality of life (QOL) and wellness. A review of a prospectively maintained database of PHPT patients (1/2016-12/2019) was performed those who had 6-month cure after initial PTX were included. The study cohort was mostly women (77%, 541/701). The median preoperative PAS was higher in women (155, 0-1190) than in men (80.5, 0-855, p
doi_str_mv 10.1016/j.surg.2023.07.044
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All PHPT patients were asked to complete symptom assessment at the preoperative and postoperative visits. The assessment included query for 13 PAS parameters evaluated using a visual analog-scale as described by Pasieka (summative score 0-1300), and general quality of life (QOL) and wellness. A review of a prospectively maintained database of PHPT patients (1/2016-12/2019) was performed those who had 6-month cure after initial PTX were included. The study cohort was mostly women (77%, 541/701). The median preoperative PAS was higher in women (155, 0-1190) than in men (80.5, 0-855, p&lt;0.001) although there were similar rates of asymptomatic PHPT (PAS=0, 12.5% v 7%, p=0.042). After curative PTX, women reported a substantial reduction in symptomatology with PAS declining by 35% at initial postoperative visit (median, 155 v 100, p&lt;0.001), further decreasing to 48% by 6 months (155 v. 80, p&lt;0.001). PAS scores in men did change but to a much smaller degree at both the initial postoperative visit (80.5 v 70; p=0.036) and at 6-months (80.5 v 57.5; p=0.048). When assessed with PAS, improvement in symptoms was clearly demonstrated for women after curative PTX. Whether symptom improvement also occurs in men is less apparent but may be due to disparities in the development and validation of outcomes tools in general.</description><identifier>ISSN: 0039-6060</identifier><identifier>EISSN: 1532-7361</identifier><identifier>DOI: 10.1016/j.surg.2023.07.044</identifier><identifier>PMID: 37980200</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><ispartof>Surgery, 2024-01, Vol.175 (1), p.65-72</ispartof><rights>2023 Elsevier Inc.</rights><rights>Copyright © 2023 Elsevier Inc. 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title Sex Differences In Patients With Primary Hyperparathyroidism
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