Mining the noncanonical terpenome

Mining the noncanonical terpenome

Terpenoids bearing carbon skeletons derived from nonisoprene units are rare and considered noncanonical. Now, a genome-mining study has uncovered previously unknown noncanonical C 16 terpenes and their biosynthetic pathways from bacteria. The findings suggest that noncanonical terpenoids are diverse...

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Veröffentlicht in:Nature chemical biology 2023-12, Vol.19 (12), p.1440-1442
Hauptverfasser: Liu, Shaonan, Lara, Darwin, Hai, Yang
Format: Artikel
Sprache:eng
Schlagworte:
631/45
639/638/60
Biochemical Engineering
Biochemistry
Bioorganic Chemistry
Biosynthesis
Carbon
Cell Biology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Enzymes
Genes
Genomes
Natural products
News & Views
news-and-views
Synthetic biology
Terpenes
Yeast
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Beschreibung
Zusammenfassung:Terpenoids bearing carbon skeletons derived from nonisoprene units are rare and considered noncanonical. Now, a genome-mining study has uncovered previously unknown noncanonical C 16 terpenes and their biosynthetic pathways from bacteria. The findings suggest that noncanonical terpenoids are diverse and widespread in nature.
ISSN:1552-4450
1552-4469
DOI:10.1038/s41589-023-01486-0