Photopromoted Free Radical Silylation of 2-Aryl-2H-indazoles with Silanes

Photopromoted Free Radical Silylation of 2-Aryl-2H-indazoles with Silanes

Photoinduced silylation of silanes with 2-aryl-2H-indazoles was developed under mild conditions, which could efficiently result in diverse 3-silylated 2H-indazoles with good substrate scopes. A series of scaled-up to gram level and radical capture operations were performed in this system. Meanwhile,...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of organic chemistry 2023-12, Vol.88 (23), p.16671-16678
Hauptverfasser: Tian, Yunfei, Zheng, Luping, Guo, Dongyu, Miao, Yuyan, Li, Lijun, Fu, Weijun, Li, Zejiang
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Photoinduced silylation of silanes with 2-aryl-2H-indazoles was developed under mild conditions, which could efficiently result in diverse 3-silylated 2H-indazoles with good substrate scopes. A series of scaled-up to gram level and radical capture operations were performed in this system. Meanwhile, a bioactive molecule was tolerated well under typical conditions.
ISSN:1520-6904
DOI:10.1021/acs.joc.3c02232