Investigation of in vitro antimicrobial and cytotoxic effects of gold nanoparticles capped with meropenem and imipenem

This study aimed to investigate the antimicrobial effect of gold nanoparticles capped with meropenem and imipenem against various strains and to evaluate the cytotoxic effect of gold nanoparticles on healthy human colon epithelial cells. Gold nanoparticles were synthesized via the Turkevich method and tested for antimicrobial effects using broth microdilution. Cell culture studies were performed using a cytotoxicity assay with alamarBlue™. Nanoparticles (10-20 nm) with antibiotic coating were more effective against , spp. and than pure antibiotics. They had a cytotoxic effect on cells at high concentrations but were safe at low concentrations.