Reduced splenic function can mimic artemisinin resistance in severe malaria

We describe severe post-treatment episodes that complicate Plasmodium falciparum malaria in patients with hyposplenism, characterized by prolonged circulation of red cells containing dead parasites (hearse red cells), persistent or recurrent fever, profound anaemia, and inflammation. Asplenia-relate...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of travel medicine 2023-12, Vol.30 (8)
Hauptverfasser:	Roussel, Camille, Serris, Alexandra, Henry, Benoît, Lafon Desmurs, Barthelemy, Sitterlé, Emilie, Bougnoux, Marie Elisabeth, Argy, Nicolas, Larréché, Sébastien, De Montalembert, Mariane, Ioos, Vincent, Tantaoui, Ilhame, Chambrion, Charlotte, Fricot, Aurélie, Rouzaud, Claire, Lanternier, Fanny, Lortholary, Olivier, Houzé, Sandrine, Jauréguiberry, Stéphane, Thellier, Marc, Ndour, Papa Alioune, Buffet, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials - pharmacology Antimalarials - therapeutic use Artemisinins - pharmacology Artemisinins - therapeutic use Drug Resistance Humans Malaria - drug therapy Malaria, Falciparum - drug therapy Plasmodium falciparum
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We describe severe post-treatment episodes that complicate Plasmodium falciparum malaria in patients with hyposplenism, characterized by prolonged circulation of red cells containing dead parasites (hearse red cells), persistent or recurrent fever, profound anaemia, and inflammation. Asplenia-related Post-antimalarial Inflammation & Hemolysis (APIH) mimics concomitant infection and parasite resistance to drugs.
ISSN:	1195-1982 1708-8305
DOI:	10.1093/jtm/taad144