CeO2 Nanoparticles to Promote Wound Healing: A Systematic Review

Cerium (Ce) is a hot topic in the field of materials research due to its electronic layer structure and the unique antioxidant abilities of its oxide (CeO2). Cerium oxide nanoparticles (CeO2 NPs) demonstrate their potential as an antioxidant and antibacterial agent. Current research focuses on whether they can be used to promote wound healing and in what manner. This article provides a systematic review of the various forms of CeO2 NPs that are used in wound‐healing materials over the past decade, as well as the effectiveness demonstrated by in vivo and in vitro experiments, with a focus on the relationship between concentration and effectiveness. CeO2 NPs are expected to become effective ingredients in dressings that require antibacterial, antioxidant, and wound healing promoting properties. This article serves as a reference for further research and clinical applications of nano‐sized CeO2 in wound healing. This article provides a systematic review of the various forms of CeO2 NPs that are used in wound‐healing materials over the past decade, as well as the effectiveness and optimal concentration. Besides, it discusses possible mechanisms behind its antioxidant, antibacterial, and wound‐healing properties, which can provide new ideas for the further research and clinical application of CeO2 NPs.