Disturbed meningeal lymphatic function associated with malignancy and progression in patients with intracranial malignant tumors

Meningeal lymphatic vessels (mLVs) have proven to bear a relationship with tumor immunity and therapeutic efficacy of intracranial malignant tumors in pre-clinical animal studies. We aimed to explore the association between mLV function and intracranial malignant tumors in clinical participants. The...

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Veröffentlicht in:Med (New York, N.Y. : Online) N.Y. : Online), 2023-12, Vol.4 (12), p.898-912.e4
Hauptverfasser: Wang, Minghuan, Ran, Lusen, Liu, Bo, Wei, Wenjie, Zhu, Jiayu, Long, Fan, Song, Xiaopeng, Zhang, Jing, Zhao, Yali, Hu, Guangyuan, Yuan, Xianglin, Wang, Wei
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Sprache:eng
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Zusammenfassung:Meningeal lymphatic vessels (mLVs) have proven to bear a relationship with tumor immunity and therapeutic efficacy of intracranial malignant tumors in pre-clinical animal studies. We aimed to explore the association between mLV function and intracranial malignant tumors in clinical participants. The participants were allocated to a control group or a group of patients with intracranial tumors. Dynamic enhanced magnetic resonance was used to evaluate the wash-in and wash-out functions of mLVs around the superior sagittal sinus and the sigmoid sinus. A total of 246 individuals were recruited for our study. The area under curve and wash-in rate of mLVs in the intracranial tumor group were higher than in the control group (2,749 vs. 2,110, p 
ISSN:2666-6340
2666-6340
DOI:10.1016/j.medj.2023.10.001