Role of Dietary Food Intake Patterns, Anthropometric Measures and Multiple Biochemical Markers in the Development of Pregnancy Specific Urinary Incontinence in Gestational Diabetes Mellitus

•The most concerned and modifiable factor, dietary food intake plays a significant role in human health.•However, less is known about the role of maternal metabolic and nutritional adaptation to pregnancy just before the Gestational Diabetes Mellitus (GDM) diagnosis on the etiology of Pregnancy Specific Urinary Incontinence (PSUI).•There was a significant decrease in calcium, polyunsaturated fats, and saturated fats in the GDM-PSUI group compared to the non-GDM-PSUI group.•Serum vitamin C was reduced in the GDM-PSUI group compared to the non-GDM-PSUI group.•Understanding the dominant mechanism predisposing to GDM may be important to provide effective treatment in order to improve perinatal outcomes. To assess maternal dietary food intake patterns, anthropometric measures, and multiple biochemical markers in Gestational Diabetes Mellitus (GDM) women with Pregnancy Specific Urinary Incontinence (PSUI) and explore whether antedating GDM environment affects the PSUI development in a cohort of pregnant women with GDM and PSUI. Maternal dietary information and anthropometric measurements were collected. At 24 weeks of gestation, with a fasting venipuncture sample, current blood samples for biochemical markers of hormones, vitamins, and minerals were analyzed. The groups were compared in terms of numerical variables using ANOVA for independent samples followed by multiple comparisons. Of the 900 pregnant women with complete data. Pregnant women in the GDM-PSUI group had higher BMI during pregnancy, arm circumference, and triceps skinfold than the non-GDM and continent (non-GDM-C) and non-GDM-PSUI groups, characterizing an obesogenic maternal environment. Regarding dietary food intake, a significant increase in aromatic amino acids, branched amino acids, dietary fiber, magnesium, zinc, and water was observed in GDM-PSUI group compared to the non-GDM-C group. Serum vitamin C was reduced in the GDM-PSUI group compared to the non-GDM-PSUI group. This study emphasizes the necessity for a comprehensive strategy for GDM women with PSUI in terms of deviation in maternal adaptation trending toward to obesity and maternal micronutrients deficiencies.