Predictors of a good diuretic response and administration methods for carperitide in patients with acute heart failure

•Predictors of good diuretic response to carperitide in patients with acute heart failure were retrospectively evaluated•Younger age (< 75 years), no prior use of loop diuretics, lower blood urea nitrogen (< 20 mg/dL) and white blood cell count (< 8.6 × 109/L) were four main predictors for good response•Carperitide administered within 2 h of intravenous furosemide yields a higher urine output•Four predictors are useful indicators to support decision-making for carperitide administration In Japan, carperitide has been recommended for the treatment of pulmonary congestion in patients with acute heart failure. Identifying useful indicators to support the decision to administer carperitide and the optimal timing of administration may lead to better improvement of pulmonary congestion. Therefore, we investigated the factors associated with a good diuretic response to carperitide in patients with acute heart failure and the optimal timing of carperitide administration. This retrospective cohort study investigated 293 hospitalized patients who were diagnosed with acute heart failure and treated with carperitide at the Department of Cardiology, XXX Hospital. The primary endpoint was the diuretic response to carperitide. Patients with urine output ≥100 mL/h were defined as the good diuretic response group, and those with a urine output