Current analytical strategies for the determination of quinolone residues in milk

•Analytical strategies for quinolone residues analysis in milk were reviewed (2012–2022).•Current sample preparation methods of LLE, SPE, and QuEChERs are discussed.•Instrument-based, immune-based, and microbial detection methods are discussed.•Method’s principles, characteristics, advantages/disadvantages are reviewed.•Future perspectives for quinolone residues determination in milk are provided. Quinolones are potent antibacterial drugs extensively utilized for treating bacterial infections in poultry. However, the presence of quinolone antibiotic residues in milk is a matter of concern due to potential health risks and adverse effects on milk quality. This review provides an overview of current analytical strategies for the determination of quinolone residues in milk. Various sample preparation techniques, such as liquid-phase extraction, solid-phase extraction and QuEChERS, are discussed, along with detection methods including instrument-based detection, immune-based detection, and microbial detection. The advantages and limitations of each method are highlighted, as well as their applicability in different stages of milk production. Additionally, recent advancements in sample preparation and detection methods are presented. This comprehensive review aims to contribute to the development of accurate and reliable methods for the detection of quinolone residues in milk, ensuring the safety and quality of dairy products.