Actionable Genotypes and Their Association with Life Span in Iceland

This study examines the relationship of pathogenic and likely pathogenic variants for which preventive or therapeutic measures are available to life span and specific causes of death.

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Veröffentlicht in:	The New England journal of medicine 2023-11, Vol.389 (19), p.1741-1752
Hauptverfasser:	Jensson, Brynjar O., Arnadottir, Gudny A., Katrinardottir, Hildigunnur, Fridriksdottir, Run, Helgason, Hannes, Oddsson, Asmundur, Sveinbjornsson, Gardar, Eggertsson, Hannes P., Halldorsson, Gisli H., Atlason, Bjarni A., Jonsson, Hakon, Oskarsson, Gudjon R., Sturluson, Arni, Gudjonsson, Sigurjon A., Thorisson, Gudmundur A., Zink, Florian, Moore, Kristjan H.S., Palsson, Gunnar, Sigurdsson, Asgeir, Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Magnusson, Magnus K., Helgadottir, Anna, Steinthorsdottir, Valgerdur, Gudmundsson, Julius, Stacey, Simon N., Hilmarsson, Rafn, Olafsson, Isleifur, Johannsson, Oskar T., Arnar, David O., Saemundsdottir, Jona, Magnusson, Olafur T., Masson, Gisli, Halldorsson, Bjarni V., Helgason, Agnar, Stefansson, Hreinn, Jonsdottir, Ingileif, Holm, Hilma, Rafnar, Thorunn, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., Stefansson, Kari, Sulem, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging General Alleles Alternative splicing Breast Cancer Cancer Cardiology Cardiology General Cardiovascular diseases Cardiovascular Diseases - genetics Confidence intervals Disease Disease - genetics Gastrointestinal Tract Cancer Genes Genetic Testing Genetic Variation Genetics Genetics General Genomes Genomics Genotype Genotype & phenotype Genotypes Geriatrics Gynecologic Oncology Hematology Humans Iceland - epidemiology Life span Longevity - genetics Neoplasms - genetics Oncology Oncology General Pathogenicity Regression analysis Survival Survival analysis
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Beschreibung
Zusammenfassung:	This study examines the relationship of pathogenic and likely pathogenic variants for which preventive or therapeutic measures are available to life span and specific causes of death.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2300792