MeCP2 is the protector of epigenome integrity, membrane-less nuclear architecture, and stability of chromatin assembly
MeCP2 is an epigenetic factor with global impact in epigenome integrity, membrane-less nuclear architecture, and chromatin stability. Our Editorial covers recent advances on these important topics. MeCP2 binding to unmethylated DNA may prevent DNA methyl transferases (DNMT) binding to DNA, inhibitin...
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| Veröffentlicht in: | Epigenomics 2023-10, Vol.15 (20), p.1027-1031 |
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| container_title | Epigenomics |
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| creator | Rastegar, Mojgan Davie, James R |
| description | MeCP2 is an epigenetic factor with global impact in epigenome integrity, membrane-less nuclear architecture, and chromatin stability. Our Editorial covers recent advances on these important topics.
MeCP2 binding to unmethylated DNA may prevent DNA methyl transferases (DNMT) binding to DNA, inhibiting 5-methylcytosine (5mC) formation. MeCP2 binding to 5mC can prevent ten-eleven translocation (TET) binding and 5-hydroxymethylcytosine (5hmC) formation. Figure created with BioRender.com with our own design. |
| doi_str_mv | 10.2217/epi-2023-0310 |
| format | Article |
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| ispartof | Epigenomics, 2023-10, Vol.15 (20), p.1027-1031 |
| issn | 1750-1911 1750-192X |
| language | eng |
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| source | MEDLINE; PubMed Central |
| subjects | Chromatin - genetics Chromatin assembly Chromatin Assembly and Disassembly DNA Methylation Epigenome Epigenomics Humans MeCP2 Methyl-CpG-Binding Protein 2 - genetics Methyl-CpG-Binding Protein 2 - metabolism nuclear architecture |
| title | MeCP2 is the protector of epigenome integrity, membrane-less nuclear architecture, and stability of chromatin assembly |
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