MeCP2 is the protector of epigenome integrity, membrane-less nuclear architecture, and stability of chromatin assembly
MeCP2 is an epigenetic factor with global impact in epigenome integrity, membrane-less nuclear architecture, and chromatin stability. Our Editorial covers recent advances on these important topics. MeCP2 binding to unmethylated DNA may prevent DNA methyl transferases (DNMT) binding to DNA, inhibitin...
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Veröffentlicht in: | Epigenomics 2023-10, Vol.15 (20), p.1027-1031 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | MeCP2 is an epigenetic factor with global impact in epigenome integrity, membrane-less nuclear architecture, and chromatin stability. Our Editorial covers recent advances on these important topics.
MeCP2 binding to unmethylated DNA may prevent DNA methyl transferases (DNMT) binding to DNA, inhibiting 5-methylcytosine (5mC) formation. MeCP2 binding to 5mC can prevent ten-eleven translocation (TET) binding and 5-hydroxymethylcytosine (5hmC) formation. Figure created with BioRender.com with our own design. |
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ISSN: | 1750-1911 1750-192X |
DOI: | 10.2217/epi-2023-0310 |