Direct arene trifluoromethylation enabled by promiscuous activity of fungal laccase

Direct arene trifluoromethylation enabled by promiscuous activity of fungal laccase

Laccase from Trametes versicolor was found to oxidize non-phenolic arenes and enable the trifluoromethylation of arenes in the presence of in situ generated CF 3 radicals at a catalyst loading as low as 0.0034%. The biocatalytic trifluoromethylation proceeded under mild conditions and could increase...

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Veröffentlicht in:Organic & biomolecular chemistry 2023-11, Vol.21 (45), p.8975-8978
Hauptverfasser: Goh, Yi Ling, Long, Shi Yang Preston, Wong, Mun Fei Eddy, Tan, Lee Ling, Tiong, Elaine, Wong, Fong Tian, Liu, Zhennan
Format: Artikel
Sprache:eng
Schlagworte:
Aromatic compounds
Catalysts
Laccase
Organic chemistry
Phenolic compounds
Phenols
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Zusammenfassung:Laccase from Trametes versicolor was found to oxidize non-phenolic arenes and enable the trifluoromethylation of arenes in the presence of in situ generated CF 3 radicals at a catalyst loading as low as 0.0034%. The biocatalytic trifluoromethylation proceeded under mild conditions and could increase the yield by up to 12 fold, compared to the control. Laccase from T. versicolor catalyzed the trifluoromethylation of non-phenolic arenes at a 0.0034% catalyst loading with a yield up to 70%.
ISSN:1477-0520
1477-0539
DOI:10.1039/d3ob01779f