Evaluating Interleukin-16 Expression in Patients with Grade-3 and Grade-4 Glial Cell Tumors and Healthy Individuals
BackgroundThis study evaluated the change in IL-16 levels in patients with high-grade glial tumors undergoing radiotherapy (RT) and healthy individuals (control group).Materials and MethodsSerum IL-16 levels of 35 high-grade glioma patients receiving radiotherapy (RT) and 30 healthy individuals were...
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Veröffentlicht in: | Nigerian journal of clinical practice 2023-10, Vol.26 (10), p.1456-1462 |
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Sprache: | eng |
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Zusammenfassung: | BackgroundThis study evaluated the change in IL-16 levels in patients with high-grade glial tumors undergoing radiotherapy (RT) and healthy individuals (control group).Materials and MethodsSerum IL-16 levels of 35 high-grade glioma patients receiving radiotherapy (RT) and 30 healthy individuals were compared. We compared the IL-16 levels before (RT0) and after the (RT1) and IL-16 levels were measured and the relationship of this change with other characteristics such as age, gender, weight, height, and blood test results.ResultsThe RT0-IL-16 level was approximately 15 pg/ml higher than the RT1 measurement in the patient group. The mean RT0-IL-16 levels in the patient group were approximately 10 pg/ml higher than the mean IL-16 levels in the control group. Likewise, at the RT1 time-point, the mean IL-16 levels for the patient group were approximately 5 pg/ml lower than the mean IL-16 for the control group. The mean RT0-RT1-IL-16 value tended to be higher in female patients than in male patients.ConclusionThe application of RT reduces the overall IL-16 levels, suggesting the efficacy of RT, as well as the role of IL-16 in tumorigenesis. |
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ISSN: | 1119-3077 2229-7731 |
DOI: | 10.4103/njcp.njcp_800_22 |