Association Between Urinary Biomarkers and CKD in Extremely Low Gestational Age Neonates

Children born before 28 weeks’ gestation are at increased risk of chronic kidney disease (CKD). Urine biomarkers may shed light on mechanistic pathways and improve the ability to forecast CKD. We evaluated whether urinary biomarkers in neonates of low gestational age (GA) are associated with a reduc...

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Veröffentlicht in:	American journal of kidney diseases 2024-04, Vol.83 (4), p.497-507
Hauptverfasser:	Brophy, Patrick, Heagerty, Patrick J., Juul, Sandra, Thomas, Billy, Mulrooney, Neil, Kase, Jordan S., Gogcu, Semsa, Ramel, Sara, Georgieff, Michael, Pfister, Katie, Roberts, Kari, Engel, Melissa, Kamrath, Heidi, Scheurer, Johannah, Satrom, Katherine, Pfister, Susan, Plummer, Erin, Williams, Jonathan, Rajderkar, Dhanashree, Northington, Frances, Valdez, Raul Chavez, Beauman, Sandra, Saurabhkumar, Patel, Serize, Arturo, Ott, Debbie, Mora, Ariana Franco, Hedrick, Pamela, Flynn, Vicki, Feltner, John B., Esposito, Isabella, Hauge, Stephanie, Purnell, Andrea, Sikes, Natalie, Mason, Melanie, McConnell, Jana, Brown, Tiffany, Pearson, Denise, Guy, Annette, Nason, Jennifer, Lee, Kristen, Penny, Sarah, Richter, Tyler, Ginder, Alexander, Rau, Carrie, McGrath, Kandace, Lewis, Kimberlee Weaver, Bird, Karie, Giblin, Clare, Daly, Rita, Wassenaar, Jenna, Ericksen, Jensina, Davern, Bridget, Osborne, Mary Pat, Gregorich, Brittany, Talele, Neha, Obregon, Evelyn, Ziyeh, Tiglath, Clarke, Molly, Barnhart, Lisa, Galvis, Edshelee M., Martinez, Denise, Bell, Suzi, Long, Corrie, McConkey, Stacy, Natarajan, Niranjana, Gaudette, Shari, Cobb, Sarah, Sharp, Gregory, Schumacher, Elizabeth, Schuschke, Leslie, Fierro, Mario, Gilmore, Lois, Hoekstra, Ronald, Cunningham, Sean, Morshedzadeh, Galina, Ostrander, Betsy, Winter, Sarah, Cox, Lauren, Rainaldi, Matthew A., Hensley, Sarah, Morris, Melissa, Boys, Christopher, Pierpont, Elizabeth I., King, Kelly E., Bergeron, Mark, Miller, Cristina, Marakovitz, Susan, Knorr, Aimee, Weissbourd, Marie, Brady, Janet, Ghosh, Suman, Lowe, Jean, Fuller, Janell, DuPont, Tara, Ohls, Robin, Patel, Saurabh, Carbonell, Lauren, de Lerma, Carmen, De Cortada, Maiana, Chavis, Lacy
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumins Biomarkers - urine Case-Control Studies Child Cohort Studies Cystatin C Erythropoietin extreme prematurity, urinary biomarkers, chronic kidney disease Gestational Age Glomerular Filtration Rate Glutathione Humans Infant Infant, Newborn Renal Insufficiency, Chronic - complications Transferases
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Zusammenfassung:	Children born before 28 weeks’ gestation are at increased risk of chronic kidney disease (CKD). Urine biomarkers may shed light on mechanistic pathways and improve the ability to forecast CKD. We evaluated whether urinary biomarkers in neonates of low gestational age (GA) are associated with a reduced estimated glomerular filtration rate (eGFR) over time. A cohort study of neonates with an exploratory case-control study of a subset of the cohort. 327 neonates born at 24-27 weeks’ gestation with 2-year eGFR data from the PENUT (Preterm Erythropoietin Neuroprotection Trial) and the REPaIReD (Recombinant Erythropoietin for Prevention of Infant Renal Disease) study. 11 urinary biomarkers measured at 27, 30, and 34 weeks’ postmenstrual age for the primary cohort study and 10 additional biomarkers for the exploratory case-control study. eGFR
ISSN:	0272-6386 1523-6838 1523-6838
DOI:	10.1053/j.ajkd.2023.09.008