Prediction of adverse outcome by ophthalmic artery Doppler and angiogenic markers in pregnancies with new onset hypertension

•Predicting PE and related maternal and neonatal outcomes is challenging•The OA PSV-ratio is a novel method for predicting PE associated adverse outcomes.•The OA PSV-ratio and Log10sFlt-1/PlGF ratio perform similarly in PE prediction. To compare the ophthalmic artery Doppler peak systolic velocity ratio (OA PSV-ratio) and soluble fms-like tyrosine kinase-1/placental growth factor ratio (sFlt-1/PlGF ratio) in predicting adverse maternal and perinatal outcomes in women presenting with new onset hypertension. Prospective cohort study in a specialist hypertension clinic, within a tertiary referral centre. Comparison between the OA PSV-ratio and sFlt-1/PlGF ratio in predicting delivery within one week from presentation and adverse maternal and perinatal outcomes e.g. severe hypertension, neonatal unit admission, small for gestational age. Women who delivered within one week, compared to those who did not, had a higher OA PSV-ratio (0.82 vs 0.71, p