HbA1c‐dependent projection of long‐term renal outcomes

HbA1c‐dependent projection of long‐term renal outcomes

Background Diabetes mellitus is a major risk factor for the development of chronic kidney disease (CKD). There is limited data addressing the value of glycated hemoglobin (HbA1c) to predict renal outcomes independent of diabetes status. Methods This single‐center retrospective observational study pr...

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Veröffentlicht in:Journal of internal medicine 2024-02, Vol.295 (2), p.206-215
Hauptverfasser: Arnold, Frederic, Kappes, Julia, Rottmann, Felix A., Westermann, Lukas, Welte, Thomas
Format: Artikel
Sprache:eng
Schlagworte:
Cholesterol
chronic kidney disease
Confidence intervals
Diabetes
Diabetes Mellitus
Diabetes Mellitus, Type 2 - complications
diabetic nephropathy
Disease Progression
Epidermal growth factor receptors
Glomerular Filtration Rate
Glycated Hemoglobin
HbA1c
Hemoglobin
Humans
Kidney
Kidney diseases
Kidneys
Observational studies
Regression analysis
Regression models
Renal Insufficiency, Chronic - complications
Risk Factors
Statistical analysis
Triglycerides
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Zusammenfassung:Background Diabetes mellitus is a major risk factor for the development of chronic kidney disease (CKD). There is limited data addressing the value of glycated hemoglobin (HbA1c) to predict renal outcomes independent of diabetes status. Methods This single‐center retrospective observational study presents data of 19,285 subjects, irrespective of initial CKD or diabetes status. The primary endpoint was defined as the time to manifestation of moderate CKD (estimated glomerular filtration rate [eGFR]
ISSN:0954-6820
1365-2796
1365-2796
DOI:10.1111/joim.13736