Photosynthetic and Self‐Draining Biohybrid Dressing for Accelerating Healing of Diabetic Wound

Wound healing is a well‐orchestrated progress associated with angiogenesis, epithelialization, inflammatory status, and infection control, whereas these processes are seriously disturbed in diabetic wounds. In this study, a biohybrid dressing integrating the inherent ability of Bromeliad leaf (photosynthesis and self‐draining) with the therapeutic effect of artificial materials (glucose‐degrading and ROS‐scavenging) is presented. The dressing consists of double‐layered structures as follows: 1) Outer layer, a Bromeliad leaf substrate full of alginate hydrogel‐immobilized glucose oxidase (GOx@Alg@Bromeliad substrate, abbreviated as BGA), can generate oxygen to guarantee the GOx‐catalyzed glucose oxidation by photosynthesis, reducing local hyperglycemia to stabilize hypoxia inducible factor‐1 alpha (HIF‐1α) for angiogenesis and producing hydrogen peroxide for killing bacteria on the surface of wound tissue. The sophisticated structure of the leaf drains excessive exudate away via transpiration‐mimicking, preventing skin maceration and impeding bacterial growth. 2) Inner layer, microneedles containing catalase (CAT‐HA MNs, abbreviated as CHM), reduces excessive oxidative stress in the tissue to promote the proliferation of fibroblasts and inhibits proinflammatory polarization of macrophages, improving re‐epithelialization of diabetic wounds. Together, the biohybrid dressing (BGA‐CHM, abbreviated as BCHM) can enhance angiogenesis, strengthen re‐epithelialization, alleviate chronic inflammation, and suppress bacterial infection, providing a promising strategy for diabetic wound therapy. The BCHM biohybrid dressing accelerates diabetic wound healing by integrating natural leaves with artificial elements. BGA, the outer layer, employs photosynthesis for oxygen generation, hyperglycemia alleviation and bacteria elimination. Its transpiration‐mimicking structure drains excessive exudate. CHM, the inner layer, contains catalase (CAT) to decrease oxidative stress and anti‐inflammation. BCHM provides a promising strategy for diabetic wound therapy.