Mechanistic insights into Thorium-232 induced liver carcinogenesis: The driving role of Wnt/β-catenin signaling pathway

Mechanistic insights into Thorium-232 induced liver carcinogenesis: The driving role of Wnt/β-catenin signaling pathway

Thorium-232 (Th-232), a naturally-occurring radioactive element with high potential of nuclear fuel is now being utilized in advanced nuclear reactors for CO2-free energy generation. To achieve all-round capability in Th-fuel cycle for health and environment, understanding the biological effects of...

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Veröffentlicht in:The Science of the total environment 2024-01, Vol.907, p.168065, Article 168065
Hauptverfasser: Yadav, Rakhee, Das, Sourav Kumar, Ali, Manjoor, Shetake, Neena G., Pandey, Badri N., Kumar, Amit
Format: Artikel
Sprache:eng
Schlagworte:
Carcinogenesis
Thorium
Transcriptomics
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Zusammenfassung:Thorium-232 (Th-232), a naturally-occurring radioactive element with high potential of nuclear fuel is now being utilized in advanced nuclear reactors for CO2-free energy generation. To achieve all-round capability in Th-fuel cycle for health and environment, understanding the biological effects of Th-232 at cellular and molecular level are extremely important. The present study investigated long-term effects (6 and 12 months) of Th-232 (4, 10 and 20 mg/kg) on gene expression in mice liver (major target organ). Analysis of differentially expressed genes (DEGs, ≥2.0 folds, p 
ISSN:0048-9697
1879-1026
1879-1026
DOI:10.1016/j.scitotenv.2023.168065