Dichapetalin-type triterpenoids from Dichapetalum longipetalum and their anti-inflammatory activity

A phytochemical research on the twigs of Dichapetalum longipetalum (Turcz.) Engl. Resulted in five undescribed dichapetalin-type triterpenoids 1–5. Their chemical structures were determined by spectroscopic analysis of HR-ESIMS and NMR spectra and the absolute configuration of compound 1 was completely elucidated by single crystal X-ray crystallography. Through preliminary anti-inflammatory activity assessment, compound 1 exhibited inhibitory effect on LPS-induced NO production in RAW264.7 murine macrophages with an IC50 value of 2.09 μM. [Display omitted] •A phytochemical research on the twigs of Dichapetalum longipetalum (Turcz.) Engl. Resulted in five undescribed dichapetalin-type triterpenoids.•The absolute stereochemistry of compound 1 were confirmed by the single crystal X-ray diffraction.•Compounds 1 exhibited more potent inhibition against NO release with IC50 of 2.09 μM than positive control dexamethasone.