Toying with reductive stress

Genetically encoded tools to manipulate redox metabolism are in high demand for investigating the underlying mechanism of cofactor imbalances in mammalian systems. A new tool enables the induction and interrogation of NADH reductive stress.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature chemical biology 2024-05, Vol.20 (5), p.542-543
Hauptverfasser:	Murphy, Alexandria C., McReynolds, Melanie R.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443/319 631/45/320 631/92/1643 631/92/607 631/92/96 Aging Biochemical Engineering Biochemistry Biology Bioorganic Chemistry Biosynthesis Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science Cholesterol Genetic code Homeostasis Humans Interrogation Metabolism Metabolites News & Views news-and-views Nicotinamide adenine dinucleotide Oxidation-Reduction Oxidative Stress Phosphates Reactive Oxygen Species - metabolism
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Beschreibung
Zusammenfassung:	Genetically encoded tools to manipulate redox metabolism are in high demand for investigating the underlying mechanism of cofactor imbalances in mammalian systems. A new tool enables the induction and interrogation of NADH reductive stress.
ISSN:	1552-4450 1552-4469
DOI:	10.1038/s41589-023-01461-9