Potential role of glutathione S‑transferase M1 gene polymorphism in kidney calcium oxalate stone formation

Background The purpose of this study was to look into the effects of glutathione S-transferase M1 ( GSTM1 ) gene polymorphism on the formation of kidney calcium oxalate stones. Methods A total of 159 patients with kidney calcium oxalate stones were included in this study as a case group. One hundred and three healthy individuals were included in the control group. The age, gender, and levels of calcium (Ca), uric acid (UA), creatinine (Cr), and urinary creatinine (Ucr) are tracked. Peripheral blood samples are used to perform a polymerase chain reaction to identify the glutathione S-transferase (GST) gene polymorphism (PCR). A commercial kit was used in this study to measure the levels of malondialdehyde (MDA), nitric oxide (NO), total antioxidant capacity (T-AOC), and 8-hydroxydeoxyguanosine (8-OHdG) in peripheral blood. Results There was no difference in age or gender distribution between the case and control groups ( P > 0.05). The Cr, Ucr, Ca, UA, 8-OHdG, MDA, NO, and T-AOC in the case group were significantly higher than those in the control group ( P 0.05). Multivariate regression analysis showed that the GSTM1 null genotype was positively correlated with 8-OHdG ( P